Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Research Unit 'Dr. Mirko Grmek', University Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia.
Eur J Cancer Prev. 2022 Mar 1;31(2):190-197. doi: 10.1097/CEJ.0000000000000679.
To examine whether there is heterogeneity in the risk factors for skin cancer among the high-risk population in Slovenia, a Central European country with the second-largest age-standardized melanoma-related mortality rate in Europe.
We analyzed data collected during the 'Euromelanoma Day' 2010-2019. The outcome was the prevalence of newly suspected skin cancer. The independent variables were 17 known risk factors and protective behaviors. We performed a latent class analysis with skin cancer as a covariate.
We analyzed data from 1711 participants with a median (interquartile range) age of 52 (39-63) years, 52% of whom were women. During the 10 years, 81 cases of melanoma and 213 cases of other skin cancers were suspected. The model with three latent classes had the best fit. Two latent classes had a high risk for melanoma and other skin cancer: 3 and 19% respectively in class 2; 14 and 29% in class 3. The largest significant differences between the two high-risk classes were the older age and lower frequency of sunscreen use in high-risk class 2 and the number of atypical nevi, a large number of common moles, many moles as the primary motive to participate in Euromelanoma examination and having a skin phototype I or II in the highest-risk latent class 3.
There is heterogeneity in the risk factors for skin cancer among the Euromelanoma high-risk population. This heterogeneity should be tested in other countries, and if the findings are consistent, they should be used to refine secondary prevention programs.
检查在欧洲标准化黑色素瘤相关死亡率第二高的中欧国家斯洛文尼亚，高危人群中皮肤癌的危险因素是否存在异质性。
我们分析了 2010 年至 2019 年“欧洲黑色素瘤日”期间收集的数据。结果是新疑似皮肤癌的患病率。自变量为 17 个已知的危险因素和保护行为。我们使用皮肤癌作为协变量进行潜在类别分析。
我们分析了来自 1711 名参与者的数据，中位数（四分位距）年龄为 52（39-63）岁，其中 52%为女性。在 10 年间，怀疑有 81 例黑色素瘤和 213 例其他皮肤癌。具有三个潜在类别的模型具有最佳拟合度。两个潜在类别具有高黑色素瘤和其他皮肤癌风险：第二类分别为 3%和 19%；第三类分别为 14%和 29%。两个高风险类别之间最大的显著差异是高危类别 2 中年龄较大和防晒霜使用频率较低，以及高危类别 3 中存在非典型痣数量较多、常见痣数量较多、作为参与 Euromelanoma 检查的主要动机的痣数量较多和皮肤光型 I 或 II。
Euromelanoma 高危人群中皮肤癌的危险因素存在异质性。这种异质性应在其他国家进行检验，如果发现一致，应将其用于完善二级预防计划。
