Lognon P, Bloc D, Saliba E, Gold F, Laugier J
l'Unité Pédiatrique de Soins Intensifs, Centre de Pédiatrie Régional et Universitaire, Tours.
Arch Fr Pediatr. 1988 Feb;45(2):127-8.
A case of subdural and intracerebral hematoma which appeared spontaneously in a neonate with severe hemophilia A is reported. This rare complication justifies some preventive measures in families at risk : antenatal ultrasonographic diagnosis of sex, vitamin K administration to the mother at the end of pregnancy and plasma assay for factors VIII and IX in the male neonate. Clinical and ultrasonographic examination of the intracranial content must be repeated during the first week of life and specific replacement therapy must be instituted if the clinical condition requires it.
本文报告了一例患有严重甲型血友病的新生儿自发出现硬膜下和脑内血肿的病例。这种罕见的并发症证明了对高危家庭采取一些预防措施的合理性：产前超声诊断胎儿性别、妊娠末期给母亲补充维生素K以及对男婴进行凝血因子VIII和IX的血浆检测。在出生后的第一周内必须反复进行颅内情况的临床和超声检查，如有临床需要，必须开始进行特异性替代治疗。
