Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St Petersburg, Russia.
Ann Hum Biol. 2021 Mar;48(2):142-149. doi: 10.1080/03014460.2021.1919204. Epub 2021 May 10.
The androgen receptor () gene contains a polymorphic trinucleotide (CAG) microsatellite repeat sequence (short or long alleles) that has been associated with fat-free mass in untrained men, which needs to be replicated in athletic cohorts.
The purpose of this study was to explore the (CAG) polymorphism in trained individuals.
A total of 61 professional bodybuilders (40 males, 21 females), 73 elite male sprinters and weightlifters and 186 male controls were enrolled in this study. The influence of the (CAG) polymorphism on muscle mass and strength was assessed in bodybuilders, while the frequencies of (CAG) alleles were compared between power athletes and non-athletes.
The polymorphism was associated with anthropometric and strength measurements in bodybuilders of both genders. Those with ≥21 CAG repeats (i.e. carriers of long alleles) exhibited greater ( < 0.05) body mass index, absolute muscle mass, arm/thigh circumference and upper/lower limb strength compared to those with <21 CAG repeats. Furthermore, carriers of ≥21 CAG repeats were more frequent among power athletes compared to controls ( = 0.0076).
Long alleles of the (CAG) polymorphism were associated with greater muscle mass and strength in bodybuilders, and power athlete status.
雄激素受体（AR）基因包含一个多态性三核苷酸（CAG）微卫星重复序列（短或长等位基因），与未经训练的男性的去脂体重有关，这需要在运动队列中复制。
本研究旨在探讨训练有素的个体中的 （CAG）多态性。
本研究共纳入 61 名职业健美运动员（40 名男性，21 名女性）、73 名精英男性短跑运动员和举重运动员以及 186 名男性对照者。在健美运动员中评估了 （CAG）多态性对肌肉质量和力量的影响，同时比较了力量运动员和非运动员之间的 （CAG）等位基因频率。
该多态性与两性健美运动员的人体测量和力量测量有关。那些具有≥21 个 CAG 重复（即长等位基因携带者）的人表现出更大的（<0.05）体重指数、绝对肌肉质量、臂/大腿围和上下肢力量，而那些具有<21 个 CAG 重复的人。此外，与对照组相比，力量运动员中携带≥21 个 CAG 重复的人更为常见（=0.0076）。
（CAG）多态性的长等位基因与健美运动员和力量运动员的更大肌肉质量和力量有关。
