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A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?

作者信息

Leonetti Alessandro, Carbone Daniela, Gregori Alessandro, Tiseo Marcello, Peters Godefridus J, Deng Dongmei, Giovannetti Elisa

机构信息

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Medical Oncology Unit, University Hospital of Parma, Parma, Italy.

出版信息

J Cancer Res Clin Oncol. 2021 Oct;147(10):3135-3137. doi: 10.1007/s00432-021-03647-x. Epub 2021 Apr 26.

DOI:10.1007/s00432-021-03647-x
PMID:33900435
Abstract
摘要

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本文引用的文献

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A multicenter clinical study: personalized medication for advanced gastrointestinal carcinomas with the guidance of patient-derived tumor xenograft (PDTX).多中心临床研究：以患者来源的肿瘤异种移植（PDTX）为指导的晚期胃肠癌个体化药物治疗。
J Cancer Res Clin Oncol. 2022 Mar;148(3):673-684. doi: 10.1007/s00432-021-03639-x. Epub 2021 Apr 17.
2
Mycoplasma hyorhinis infection promotes tyrosine kinase inhibitor (TKI) resistance in lung adenocarcinoma patients.解脲支原体感染促进肺腺癌患者对酪氨酸激酶抑制剂（TKI）的耐药性。
J Cancer Res Clin Oncol. 2021 May;147(5):1379-1388. doi: 10.1007/s00432-021-03547-0. Epub 2021 Feb 6.
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The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer.
微生物组在癌症及治疗疗效中的作用：聚焦肺癌
Anticancer Res. 2020 Sep;40(9):4807-4818. doi: 10.21873/anticanres.14484.
4
Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer.奥希替尼治疗 EGFR 突变型非小细胞肺癌的耐药机制。
Br J Cancer. 2019 Oct;121(9):725-737. doi: 10.1038/s41416-019-0573-8. Epub 2019 Sep 30.
5
Pharmacogenetics of treatments for pancreatic cancer.胰腺癌治疗的药物遗传学。
Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):437-447. doi: 10.1080/17425255.2019.1620731. Epub 2019 May 24.
6
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.RX-3117（氟环戊基胞嘧啶）：一种新型的特异性抗癌代谢物，用于选择性癌症治疗。
Expert Opin Investig Drugs. 2019 Apr;28(4):311-322. doi: 10.1080/13543784.2019.1583742. Epub 2019 Mar 16.
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Targeting exon 20 insertion mutations in non-small cell lung cancer.针对非小细胞肺癌中的外显子 20 插入突变。
Signal Transduct Target Ther. 2019 Mar 8;4:5. doi: 10.1038/s41392-019-0038-9. eCollection 2019.
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The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.胰腺癌的微生物组学：从分子诊断到克服吉西他滨代谢失活引起的化疗耐药的新治疗方法。
Expert Rev Mol Diagn. 2018 Dec;18(12):1005-1009. doi: 10.1080/14737159.2018.1544495. Epub 2018 Nov 9.
9
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.肿瘤内细菌在介导肿瘤对化疗药物吉西他滨耐药中的潜在作用。
Science. 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043.
10
Impact of smoking status on EGFR-TKI efficacy for advanced non-small-cell lung cancer in EGFR mutants: a meta-analysis.吸烟状态对表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKI）治疗表皮生长因子受体（EGFR）突变的晚期非小细胞肺癌疗效的影响：一项荟萃分析
Clin Lung Cancer. 2015 Mar;16(2):144-151.e1. doi: 10.1016/j.cllc.2014.09.008. Epub 2014 Oct 2.