Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
Antiaging Center, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
J Nat Med. 2021 Jun;75(3):449-466. doi: 10.1007/s11418-021-01522-0. Epub 2021 Apr 26.
During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (1) and neokotalanol (4), and related thiosugar sulfoniums, from the roots and stems of the genus Salacia plants [Celastraceae (Hippocrateaceae)] such as Salacia reticulata Wight, S. oblonga Wall., and S. chinensis L., and observed their antidiabetic effects. These plant materials have been used traditionally in Ayurvedic medicine as a specific remedy at the early stage of diabetes, and have been extensively consumed in Japan, the United States, and other countries as a food supplement for the prevention of obesity and diabetes. Here, we review our studies on the antidiabetic effects of plants from the genus Salacia, from basic chemical and pharmacological research to their application and development as new functional food ingredients.
在研究从食物资源中提取的功能性物质以预防和治疗生活方式相关疾病的过程中，我们从藤黄科藤黄属植物（Salacia）的根和茎中分离出了活性成分salacinol（1）和 neokotalanol（4）以及相关的硫代糖磺酸，这些植物包括 Salacia reticulata Wight、S. oblonga Wall. 和 S. chinensis L.，并观察到它们具有抗糖尿病作用。这些植物材料在传统的阿育吠陀医学中被用作糖尿病早期的特定疗法，在日本、美国和其他国家被广泛用作预防肥胖和糖尿病的食品补充剂。在这里，我们回顾了我们对 Salacia 属植物的抗糖尿病作用的研究，从基础的化学和药理学研究到将其作为新型功能性食品成分的应用和开发。
