Whittington R J, Glastonbury J R, Plant J W, Barry M R
New South Wales Department of Agriculture, Regional Veterinary Laboratory.
Aust Vet J. 1988 Apr;65(4):124-7. doi: 10.1111/j.1751-0813.1988.tb14431.x.
A syndrome of congenital malformations in Corriedale sheep characterised by brachygnathia inferior, campylognathia, tetraemlic arthrogryposis, kyphoscoliosis, hydranencephaly and hypoplasia of the brain stem, cerebellum and spinal cord occurring in various combinations is described. Histologically there was generalised hypomyelinogenesis and hypoplasia of the central nervous system with neurogenic atrophy of skeletal muscle. The syndrome resembled that caused by congenital infection with Akabane virus, however, serological, pathological and epidemiological data indicated that Akabane virus was not involved. The results of a breeding trial suggested that the disorder may be transmitted with an autosomal recessive mode of inheritance.
描述了一种发生于考力代绵羊的先天性畸形综合征，其特征为下颌后缩、弯颌、四肢关节弯曲、脊柱侧凸、积水性无脑畸形以及脑干、小脑和脊髓发育不全，这些症状以各种组合形式出现。组织学检查显示，中枢神经系统普遍存在髓鞘形成不足和发育不全，同时伴有骨骼肌神经源性萎缩。该综合征类似于由赤羽病毒先天性感染引起的综合征，然而，血清学、病理学和流行病学数据表明，赤羽病毒与此无关。一项繁殖试验结果表明，这种疾病可能以常染色体隐性遗传模式进行传播。
