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腰椎硬膜外区域的一种罕见实体:T细胞淋巴母细胞淋巴瘤。

A Rare Entity in the Lumbar Epidural Region: T-Cell Lymphoblastic Lymphoma.

作者信息

Erdem Münibe Büşra, Kale Aydemir, Yaman Mesut Emre, Emmez Hakan

机构信息

Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.

出版信息

Int J Spine Surg. 2021 Feb;14(s4):S52-S56. doi: 10.14444/7165. Epub 2021 Jan 18.

Abstract

BACKGROUND

T-cell lymphoblastic lymphoma is a rare disease and an aggressive neoplasm of precursor lymphoblasts. We present a case of lumbar epidural T-cell lymphoblastic lymphoma which appeared with clinical features of epidural spinal cord compression.

METHODS

A 38-year-old male patient presented with weakness in the lower extremities and newly developed urinary incontinence. His medical history included precursor T-cell acute lymphoblastic leukemia and treatment with allogeneic bone-marrow transplantation 5 years previously. Spinal magnetic resonance imaging (MRI) revealed an epidural mass lesion at L2-L4 levels and there was no sign of leukemia or lymphoma in clinical, laboratory, and radiological examinations. Surgery was planned for obtaining diagnostic material. Decompressive laminectomy and subtotal excision of the tumor were performed.

RESULTS

At surgery, the tumor consisted of yellow-colored and hypovascular soft tissue fragments. It was encircling the spinal cord and spreading through the left L3 foramen. The patient underwent adjuvant chemoradiotherapy after the histopathological evaluation. At 2-month follow-up, the patient was able to walk without assistance, but the urinary incontinence was the same. At 5-month follow-up, the disease progressed, and the patient passed away because of infective endocarditis.

CONCLUSION

Spinal lymphomas may display its characteristic "wrap-around" fashion in the MRI. In this report, we shared the microsurgical appearance of this fashion. As the lymphomas are chemoradiosensitive tumors, the treatment should be managed with a multidisciplinary approach.

摘要

背景

T 细胞淋巴母细胞淋巴瘤是一种罕见疾病,是前体淋巴母细胞的侵袭性肿瘤。我们报告一例腰椎硬膜外 T 细胞淋巴母细胞淋巴瘤,其临床表现为硬膜外脊髓压迫。

方法

一名 38 岁男性患者出现下肢无力和新出现的尿失禁。他的病史包括前体 T 细胞急性淋巴细胞白血病,5 年前接受过异基因骨髓移植治疗。脊髓磁共振成像(MRI)显示 L2-L4 水平有硬膜外肿块病变,临床、实验室和影像学检查均未发现白血病或淋巴瘤迹象。计划进行手术以获取诊断材料。实施了减压性椎板切除术和肿瘤次全切除术。

结果

手术时,肿瘤由黄色、血供少的软组织碎片组成。它环绕脊髓并通过左 L3 椎间孔扩散。患者在组织病理学评估后接受了辅助放化疗。在 2 个月的随访中,患者能够独立行走,但尿失禁情况未改善。在 5 个月的随访中,疾病进展,患者因感染性心内膜炎去世。

结论

脊髓淋巴瘤在 MRI 上可能呈现其特征性的“包绕”方式。在本报告中,我们分享了这种方式的显微手术表现。由于淋巴瘤是放化疗敏感肿瘤,治疗应采用多学科方法。

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