Zhang Yao, Li Kongdong, Kong Anqi, Zhou Yang, Chen Dongfeng, Gu Jie, Shi Haifeng
School of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212000, China.
Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Ecotoxicol Environ Saf. 2021 Jul 1;217:112256. doi: 10.1016/j.ecoenv.2021.112256. Epub 2021 Apr 23.
Non-alcoholic fatty liver disease (NAFLD) has been the most common chronic liver disease in the world, including the developing countries. NAFLD is metabolic disease with significant lipid deposition in the hepatocytes of the liver, which is usually associated with oxidative stress, inflammation and fibrogenesis, and insulin resistance. Progressive NAFLD can develop into non-alcoholic steatohepatitis (NASH) or hepatocellular carcinoma. The current evidence proposes that environmental pollutants promote development and progression of NAFLD, and autophagy plays a vital role but is multifactorial affected in NAFLD. In this review, we analyzed on the regulations of common environmental pollutants on autophagy in NAFLD. To clarify the involved roles of autophagy, we discussed the dysregulation of autophagy by environmental pollutants in adipose tissue and gut, and their interactions with liver, as well as epigenetic regulation on autophagy by environmental pollutants. Furthermore, protective roles of potential therapeutic treatments on the multiple-hits of autophagy in NAFLD were descripted.
非酒精性脂肪性肝病（NAFLD）已成为包括发展中国家在内的全球最常见的慢性肝病。NAFLD是一种代谢性疾病，肝脏肝细胞中有大量脂质沉积，通常与氧化应激、炎症、纤维化以及胰岛素抵抗有关。进展性NAFLD可发展为非酒精性脂肪性肝炎（NASH）或肝细胞癌。目前的证据表明，环境污染物会促进NAFLD的发生和发展，自噬在其中起着至关重要的作用，但在NAFLD中受到多种因素的影响。在本综述中，我们分析了常见环境污染物对NAFLD自噬的调控作用。为阐明自噬所涉及的作用，我们讨论了环境污染物在脂肪组织和肠道中对自噬的失调作用，以及它们与肝脏的相互作用，还有环境污染物对自噬的表观遗传调控。此外，还描述了潜在治疗方法对NAFLD自噬多重打击的保护作用。
