绵羊组织中肌酸代谢的定量研究。

Quantitative study on creatine metabolism in sheep tissues.

作者信息

Xue G P, Snoswell A M, Fishlock R C

机构信息

Department of Animal Sciences, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia 5064.

出版信息

Biochem Int. 1988 Apr;16(4):623-8.

PMID:3390194

Abstract

Creatine metabolism was quantitated in sheep tissues by measurement of the amount of creatine and creatinine flowing into and out of various tissues using multi-catheterized sheep. The results showed that sheep derived no creatine from the digestive tract. The total renal clearance of creatine plus creatinine was about 18 mmoles per day. Daily creatine synthesis in the sheep was some 15 mmoles, of which 80% occurred in the liver. There was a daily uptake of about 5.4 mmoles of creatine and an output of 7.8 mmoles of creatinine by the hindlimbs of the sheep. This difference suggests that the skeletal muscle may be able to synthesize a significant amount of creatine. However, creatine metabolism in the heart, lung and brain was much less active.

摘要

通过使用多导管插入的绵羊，测量进出各种组织的肌酸和肌酐的量，对绵羊组织中的肌酸代谢进行了定量分析。结果表明，绵羊不从消化道获取肌酸。肌酸加肌酐的总肾清除率约为每天18毫摩尔。绵羊每天的肌酸合成量约为15毫摩尔，其中80%发生在肝脏。绵羊后肢每天摄取约5.4毫摩尔的肌酸，排出7.8毫摩尔的肌酐。这种差异表明骨骼肌可能能够合成大量的肌酸。然而，心脏、肺和大脑中的肌酸代谢活性要低得多。