[肝硬化与继发性骨质疏松症]

[Liver cirrhosis and secondary osteoporosis].

作者信息

Yang L, Yang C Q

机构信息

Division of Gastroenterology and Hepatology, Digestive Disease Institute, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2021 Mar 20;29(3):204-208. doi: 10.3760/cma.j.cn501113-20210208-00078.

DOI:10.3760/cma.j.cn501113-20210208-00078

PMID:33902185

Abstract

Osteoporosis is a bone loss disease caused by the imbalance of osteoblast and osteoclast. It is a common complication of patients with liver cirrhosis, cholestatic liver disease, and liver transplantation. Over the past few decades, many researchs have raised the awareness of immune cell activation, chronic inflammation, intestinal microflora, etc. in liver cirrhosis and secondary osteoporosis. This article reviews the progress of the epidemiology, pathogenesis, diagnosis and treatment of liver cirrhosis and secondary osteoporosis.

摘要

骨质疏松症是一种由成骨细胞和破骨细胞失衡引起的骨质流失疾病。它是肝硬化、胆汁淤积性肝病和肝移植患者的常见并发症。在过去几十年中，许多研究提高了人们对肝硬化和继发性骨质疏松症中免疫细胞激活、慢性炎症、肠道微生物群等方面的认识。本文综述了肝硬化和继发性骨质疏松症在流行病学、发病机制、诊断和治疗方面的进展。