Tian F, Liu D W, Pan S K, Li Z Y, Duan J Y, Yang J, Liu Z S
Department of Nephrology, the First Affiliated Hospital of Zhengzhou University/Research Institute of Nephrology of Zhengzhou University/Research Center for Kidney Disease, Henan Province/Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province/Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou 450052, China.
Zhonghua Yi Xue Za Zhi. 2021 Apr 27;101(16):1149-1153. doi: 10.3760/cma.j.cn112137-20210123-00227.
To explore the relationship between polycyclic aromatic hydrocarbons (PAHs), the major component of atmospheric pollutant particulate matter 2.5 (PM) and idiopathic membranous nephropathy (IMN) and its possible mechanisms. Thirty-five (24 males and 11 females) patients with IMN confirmed by renal biopsy pathology in the First Affiliated Hospital of Zhengzhou University from June to September 2020 were selected as the research group, with an age of (47.3±12.9) years. Meanwhile, patients with secondary membranous nephropathy (SMN, =10) and minimal-change disease (MCD, =10) were selected as control group. Blood samples were collected to detect PAHs and heme oxygenase-1 (HO-1), and the relationship of PAHs with clinical indicators and oxidative stress indicator HO-1 was analyzed. Compared with SMN and MCD groups [(2.6±1.7) mg/L and (2.8±1.0) mg/L], the concentration of PAHs in IMN group [(4.1±1.9) mg/L] increased (both <0.05). The concentration of PAHs was positively correlated with the levels of β2 microglobulin, total cholesterol and 24-hour urine total protein (=0.509, 0.336, and 0.653, respectively, all <0.05), but was negatively correlated with the levels of total protein and albumin (=-0.499,-0.530, respectively, both <0.05). Additionally, the concentration of PAHs was negatively correlated with the level of HO-1 (=-0.358, =0.017). Linear regression analysis showed that the concentration of HO-1 decreased by 1.737 μg/L when the concentration of PAHs increased by 1 mg/L (=0.035). PAHs have a high level in IMN patients, and may be involved in the occurrence and development of IMN through oxidative stress.
