Research Center of the Institut Universitaire en Santé Mentale de Montréal, Montreal, Quebec, Canada.
Department of Psychiatry and Addictology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
Psychol Med. 2021 Jun;51(8):1249-1259. doi: 10.1017/S0033291721001525. Epub 2021 Apr 27.
In the past decade, there has been a growing interest in examining resting-state functional connectivity deficits in subjects with conduct and antisocial personality disorder. Through meta-analyses and literature reviews, extensive work has been done to characterize their abnormalities in brain activation during a wide range of functional magnetic resonance imaging (fMRI) tasks. However, there is currently no meta-analytical evidence regarding neural connectivity patterns during resting-state fMRI. Therefore, we conducted a coordinate-based meta-analysis of resting-state fMRI studies on individuals exhibiting antisocial behaviors. Of the retrieved studies, 18 used a seed-based connectivity approach (513 cases 488 controls), 20 employed a non-seed-based approach (453 cases 460 controls) and 20 included a correlational analysis between the severity of antisocial behaviors and connectivity patterns (3462 subjects). Meta-analysis on seed-based studies revealed significant connectivity deficits in the amygdala, middle cingulate cortex, ventral posterior cingulate cortex-precuneus, ventromedial and dorsomedial prefrontal cortex, premotor cortex, and superior parietal lobule. Additionally, non-seed-based meta-analysis showed increased connectivity in the ventral posterior cingulate cortex and decreased connectivity in the parietal operculum, calcarine cortex, and cuneus. Finally, we found meta-analytical evidence for negative relationship between the severity of antisocial behaviors and connectivity with the ventromedial prefrontal cortex. Functional characterization and meta-analytical connectivity modeling indicated that these findings overlapped with socio-affective and attentional processes. This further underscores the importance of these functions in the pathophysiology of conduct and antisocial personality disorders.
在过去的十年中，人们对检查有品行障碍和反社会人格障碍的受试者的静息态功能连接缺陷越来越感兴趣。通过荟萃分析和文献综述，已经进行了广泛的工作来描述他们在广泛的功能磁共振成像（fMRI）任务中大脑激活的异常。然而，目前关于静息态 fMRI 期间神经连接模式尚无荟萃分析证据。因此，我们对表现出反社会行为的个体的静息态 fMRI 研究进行了基于坐标的荟萃分析。在检索到的研究中，有 18 项使用了基于种子的连接方法（513 例 488 例对照），20 项使用了非基于种子的方法（453 例 460 例对照），20 项包括反社会行为严重程度与连接模式之间的相关性分析（3462 名受试者）。基于种子的研究的荟萃分析显示，杏仁核、中扣带回、腹侧后扣带回-楔前叶、腹侧和背侧前额叶、前运动皮层和顶叶上回的连接存在明显缺陷。此外，非基于种子的荟萃分析显示，后扣带回腹侧的连接增加，顶下叶、距状裂皮质和楔前叶的连接减少。最后，我们发现反社会行为严重程度与腹内侧前额叶连接之间存在负相关的荟萃分析证据。功能特征和荟萃分析连接建模表明，这些发现与社会情感和注意力过程重叠。这进一步强调了这些功能在品行障碍和反社会人格障碍的病理生理学中的重要性。
