Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Paris Brain Institute, Sorbonne University/CNRS/INSERM, Paris, France.
Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA.
Neurosci Biobehav Rev. 2022 Apr;135:104583. doi: 10.1016/j.neubiorev.2022.104583. Epub 2022 Feb 22.
This review synthesizes relations between mindfulness and resting-state fMRI functional connectivity of brain networks. Mindfulness is characterized by present-moment awareness and experiential acceptance, and relies on attention control, self-awareness, and emotion regulation. We integrate studies of functional connectivity and (1) trait mindfulness and (2) mindfulness meditation interventions. Mindfulness is related to functional connectivity in the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. Specifically, mindfulness-mediated functional connectivity changes include (1) increased connectivity between posterior cingulate cortex (DMN) and dorsolateral prefrontal cortex (FPN), which may relate to attention control; (2) decreased connectivity between cuneus and SN, which may relate to self-awareness; (3) increased connectivity between rostral anterior cingulate cortex region and dorsomedial prefrontal cortex (DMN) and decreased connectivity between rostral anterior cingulate cortex region and amygdala region, both of which may relate to emotion regulation; and lastly, (4) increased connectivity between dorsal anterior cingulate cortex (SN) and anterior insula (SN) which may relate to pain relief. While further study of mindfulness is needed, neural signatures of mindfulness are emerging.
这篇综述综合了正念与静息态 fMRI 脑网络功能连接之间的关系。正念的特点是对当下的觉察和体验式接纳，依赖于注意力控制、自我意识和情绪调节。我们整合了功能连接和（1）特质正念和（2）正念冥想干预的研究。正念与默认模式网络（DMN）、额顶网络（FPN）和突显网络（SN）的功能连接有关。具体来说，正念介导的功能连接变化包括：（1）后扣带回皮质（DMN）和背外侧前额叶皮质（FPN）之间的连接增加，这可能与注意力控制有关；（2）楔前叶和 SN 之间的连接减少，这可能与自我意识有关；（3）前扣带皮质区域与背内侧前额叶皮质（DMN）之间的连接增加，前扣带皮质区域与杏仁核区域之间的连接减少，这两者都可能与情绪调节有关；最后，（4）背侧前扣带皮质（SN）和前岛叶（SN）之间的连接增加，这可能与缓解疼痛有关。虽然需要进一步研究正念，但正念的神经特征正在显现。
