Faculty of Science, Department of Organic Chemistry, 30 quai Ernest Ansermet, CH-1211 Geneva 4;, Email:
Chimia (Aarau). 2021 Apr 28;75(4):319-322. doi: 10.2533/chimia.2021.319.
Cellular homeostasis importantly relies on the correct nucleoplasmic distribution of a large number of RNA molecules and proteins, which are shuttled by specialized transport receptors. The nuclear import receptor importin-5, also called IPO5, RanBP5 or karyopherin β3, mediates the translocation of proteins to the nucleus, and thus regulates critical signaling pathways and cellular functions. The normal function of IPO5 appears to be disrupted in cancer cells due to aberrant overexpression. IPO5 also demonstrated a pivotal role in viral replication. The constant increasing number of publications shows an interest within the scientific community as a therapeutic target due to its pivotal role in protein trafficking.
细胞内稳态的维持依赖于大量 RNA 分子和蛋白质在核质间的正确分布，这些 RNA 分子和蛋白质是通过专门的运输受体穿梭运输的。核输入受体 importin-5，也称为 IPO5、RanBP5 或核转运蛋白β3，介导蛋白质向核内的转运，从而调节关键的信号通路和细胞功能。由于异常过表达，IPO5 在癌细胞中的正常功能似乎被打乱。IPO5 在病毒复制中也发挥了关键作用。由于其在蛋白质运输中的关键作用，越来越多的出版物表明科学界对此产生了兴趣，将其作为治疗靶点。
