Corteva Agriscience, 7300 NW 62nd Avenue, Johnston, IA, 50131, USA.
Corteva Agriscience, 7300 NW 62nd Avenue, Johnston, IA, 50131, USA.
Plant Sci. 2021 Jun;307:110899. doi: 10.1016/j.plantsci.2021.110899. Epub 2021 Mar 30.
Corteva Agriscience™ ran a discovery research program to identify biotech leads for improving maize Agronomic Traits such as yield, drought tolerance, and nitrogen use efficiency. Arising from many discovery sources involving thousands of genes, this program generated over 3331 DNA cassette constructs involving a diverse set of circa 1671 genes, whose transformed maize events were field tested from 2000 to 2018 under managed environments designed to evaluate their potential for commercialization. We demonstrate that a subgroup of these transgenic events improved yield in field-grown elite maize breeding germplasm. A set of at least 22 validated gene leads are identified and described which represent diverse molecular and physiological functions. These leads illuminate sectors of biology that could guide crop improvement in maize and perhaps other crops. In this review and interpretation, we share some of our approaches and results, and key lessons learned in discovering and developing these maize Agronomic Traits leads.
科迪华农业科技™开展了一项发现研究计划，旨在寻找生物技术的先导，以提高玉米的农艺性状，如产量、耐旱性和氮利用效率。该计划源自涉及数千个基因的多个发现来源，生成了 3331 多个 DNA 盒构建体，涉及约 1671 个基因的多样化组合，这些基因的转化玉米事件在 2000 年至 2018 年期间在受控环境下进行了田间测试，旨在评估其商业化潜力。我们证明，这些转基因事件中的一个亚组提高了田间生长的优良玉米育种种质的产量。确定并描述了至少 22 个经过验证的基因先导，它们代表了多样化的分子和生理功能。这些先导揭示了生物学的各个领域，这些领域可能指导玉米和其他作物的改良。在这篇综述和解释中，我们分享了我们在发现和开发这些玉米农艺性状先导方面的一些方法和结果，以及关键的经验教训。
