肝 MRI 肝胆期定量肝门静脉对比率的截断值评估。
Assessment of the cut-off value of quantitative liver-portal vein contrast ratio in the hepatobiliary phase of liver MRI.
机构信息
Department of Radiological Technology, Faculty of Health and Welfare, Tokushima Bunri University, 1314-1 Shido, Sanuki-city, Kagawa, 769-2193, Japan; Department of System Control Engineering, Graduate School of Engineering, Tokushima Bunri University, 1314-1 Shido, Sanuki-city, Kagawa, 769-2193, Japan; Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan.
Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, 920-0942, Japan; Department of Radiology, Otsu City Hospital, 2-9-9, Motomiya, Otsu-city, Shiga, 520-0804, Japan.
出版信息
Clin Radiol. 2021 Jul;76(7):551.e17-551.e24. doi: 10.1016/j.crad.2021.03.015. Epub 2021 Apr 24.
AIM
To calculate the quantitative liver-portal vein contrast ratio (Q-LPC) cut-off value based on tumour detectability by using receiver operating characteristic (ROC) curves.
MATERIALS AND METHODS
Seventy-four patients with tumours (46 men and 28 women; age, 71 ± 8.1 years), who underwent liver magnetic resonance imaging (MRI) using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) were enrolled. Some patients were found to have multiple tumours. In total, 102 tumour images were evaluated for quantitative liver-spleen contrast ratio (Q-LSC) and Q-LPC 10 minutes after the administration of Gd-EOB-DTPA. Q-LPC and Q-LSC were compared to assess the cut-off values and usefulness. The ROC curve was evaluated using the method for continuously distributed test results, with a free scale of 50 mm. A score of ≥30 out of 50 points was considered good. Cut-off values of Q-LPC and Q-LSC were then calculated. The areas under the ROC curve (AUCs) were also examined and compared.
RESULTS
The AUC-ROC for Q-LPC was 0.858 (95% confidence interval [CI], 0.783-0.933). The cut-off value was determined to be at 1.462. Sensitivity was 0.747, and specificity was 0.852 at the cut-off value. The AUC-ROC for Q-LSC was 0.710 (95% CI, 0.597-0.822). The cut-off value was at 1.543, the sensitivity was 0.560, and the specificity was 0.778 at the cut-off value. A significant difference was noted between the AUCs (p=0.0016).
CONCLUSION
Q-LPC can be used for hepatobiliary phase MRI evaluation.
目的
通过使用受试者工作特征（ROC）曲线计算基于肿瘤可探测性的定量肝门静脉对比率（Q-LPC）截断值。
材料与方法
共纳入 74 例（男 46 例，女 28 例；年龄 71±8.1 岁）接受钆乙氧基苯甲基二乙三胺五乙酸（Gd-EOB-DTPA）肝磁共振成像（MRI）检查的肿瘤患者。部分患者存在多个肿瘤。共评估了 102 个肿瘤图像的定量肝脾对比率（Q-LSC）和 Gd-EOB-DTPA 给药后 10 分钟的 Q-LPC。通过比较 Q-LPC 和 Q-LSC 来评估截断值和有用性。采用连续分布检验结果的方法评估 ROC 曲线，自由标度为 50mm。得分≥50 分中的 30 分被认为是好的。然后计算 Q-LPC 和 Q-LSC 的截断值。还检查和比较了 ROC 曲线下面积（AUCs）。
结果
Q-LPC 的 ROC-AUC 为 0.858（95%置信区间 [CI]，0.783-0.933）。确定截断值为 1.462。在该截断值时，灵敏度为 0.747，特异性为 0.852。Q-LSC 的 ROC-AUC 为 0.710（95%CI，0.597-0.822）。截断值为 1.543，灵敏度为 0.560，特异性为 0.778。AUCs 之间存在显著差异（p=0.0016）。
结论
Q-LPC 可用于肝胆期 MRI 评估。
Zotero 插件