Department of Innovative Biomedical Visualization (iBMV), Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 464-8601, Japan.
Magn Reson Imaging Clin N Am. 2021 May;29(2):243-251. doi: 10.1016/j.mric.2021.01.002.
The glymphatic system hypothesis is associated with the circulation of cerebrospinal fluid (CSF) in the skull and interstitial fluid (ISF) in the brain. There are several imaging techniques to visualize the dynamics of CSF and ISF. Magnetic resonance imaging (MRI) is one of the promising modalities for glymphatic imaging and diffusion MRI is expected imaging tool. Several disorders are associated with glymphatic dysfunction or impairment in the dynamics of CSF or ISF. The Central Nervous System interstitial fluidopathy concept has been proposed to encompass diseases with pathologies that are predominantly associated with abnormal ISF/CSF dynamics.
糖质新生系统假说与脑脊液（CSF）在颅骨中的循环和脑内间质液（ISF）有关。有几种成像技术可用于观察 CSF 和 ISF 的动力学。磁共振成像（MRI）是糖质新生成像的一种有前途的方式，扩散 MRI 是一种预期的成像工具。几种疾病与 CSF 或 ISF 动力学的糖质新生功能障碍或损害有关。中枢神经系统间质液病概念的提出是为了包含主要与异常 ISF/CSF 动力学相关的病理的疾病。
