Department of Innovative Biomedical Visualization (iBMV), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jpn J Radiol. 2021 Jan;39(1):1-14. doi: 10.1007/s11604-020-01017-0. Epub 2020 Jul 11.
After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer's disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose "Central Nervous System (CNS) Interstitial Fluidopathy" as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as "CNS interstitial fluidopathies," will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for "CNS interstitial fluidopathies."
在糖质新生系统假说提出后，人们对大脑中的脑脊液和细胞间液动力学进行了越来越多的研究和报道。一系列疾病的发生与糖质新生系统异常有关，包括阿尔茨海默病、创伤性脑损伤、中风或其他疾病。这些疾病或障碍具有糖质新生系统功能障碍或与细胞间液动力学相关的其他机制的特征。在这篇综述文章中，我们提出“中枢神经系统（CNS）细胞间液病”作为一个新概念，涵盖了主要与异常细胞间液动力学相关的病理学的疾病。将这些疾病或障碍归类为“CNS 细胞间液病”，将有助于理解其机制，并开发潜在的疾病评估成像方法和临床治疗或预防疾病的方法。换句话说，从细胞间液动力学的角度来看，对于理解中枢神经系统疾病或障碍具有重要意义，并且有可能为“CNS 细胞间液病”开发新的通用治疗方法或药物。
