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根治性子宫颈切除术(radical trachelectomy)后妊娠的管理。

Management of pregnancy after radical trachelectomy.

机构信息

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

出版信息

Gynecol Oncol. 2021 Jul;162(1):220-225. doi: 10.1016/j.ygyno.2021.04.023. Epub 2021 Apr 24.

DOI:10.1016/j.ygyno.2021.04.023
PMID:33902946
Abstract

Radical trachelectomy (RT) is a surgery for early-stage cervical cancer treatment that preserves the childbearing ability, and its use has become increasingly common worldwide. Thus, the rate of conception in women who have undergone RT is increasing. However, pregnancy after RT is associated with a higher risk of several obstetric complications such as preterm delivery, preterm premature membrane rupture, and abnormal bleeding from varices at the site of uterovaginal anastomosis. Furthermore, since RT have a residual prophylactic cerclage, it is difficult to manage first- and second-trimester miscarriages. There is little previous data on the management of pregnancy after RT. In this review article, we summarize various management methods and experiences to provide a guide to clinicians for perinatal management after RT.

摘要

根治性子宫颈切除术(RT)是一种治疗早期宫颈癌的手术,可以保留生育能力,在世界范围内的应用越来越普遍。因此,接受 RT 的女性的妊娠率正在上升。然而,RT 后妊娠与多种产科并发症的风险增加相关,例如早产、胎膜早破和阴道子宫吻合部位静脉曲张出血。此外,由于 RT 有残余预防性宫颈环扎术,因此很难处理第一和第二孕期的流产。以前关于 RT 后妊娠管理的数据很少。在这篇综述文章中,我们总结了各种管理方法和经验,为 RT 后围产期管理提供临床医生的指导。

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1
Management of pregnancy after radical trachelectomy.根治性子宫颈切除术(radical trachelectomy)后妊娠的管理。
Gynecol Oncol. 2021 Jul;162(1):220-225. doi: 10.1016/j.ygyno.2021.04.023. Epub 2021 Apr 24.
2
Expectant management for early pregnancy miscarriage after radical trachelectomy: A single hospital-based study.根治性宫颈切除术治疗早孕流产的期待管理:单中心研究。
Acta Obstet Gynecol Scand. 2021 Jul;100(7):1322-1325. doi: 10.1111/aogs.14158. Epub 2021 Apr 12.
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Pregnancy outcomes following radical trachelectomy for early-stage cervical cancer: A retrospective observational study in the Kanto area, Japan.早期宫颈癌根治性宫颈切除术后的妊娠结局:日本关东地区的一项回顾性观察研究。
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Oncologic and obstetric outcomes and complications during pregnancy after fertility-sparing abdominal trachelectomy for cervical cancer: a retrospective review.宫颈癌保留生育功能的腹式宫颈切除术术后妊娠期间的肿瘤学和产科结局及并发症:一项回顾性研究
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Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy.根治性宫颈切除术后因宫颈机能不全行经腹宫颈环扎术后成功分娩。
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Pregnancy Outcomes After Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer: A 13-Year Experience in a Single Tertiary-Care Center.早期宫颈癌腹式根治性宫颈切除术后的妊娠结局:一家三级医疗中心的13年经验
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Pregnancies after vaginal radical trachelectomy (RT) in patients with early invasive uterine cervical cancer: results from a single institute.阴道根治性子宫颈切除术(RT)治疗早期浸润性宫颈癌后的妊娠结局:单中心研究结果。
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Reproductive and obstetric outcomes after abdominal radical trachelectomy (ART) for patients with early-stage cervical cancers in Fudan, China.中国复旦大学行腹式根治性宫颈切除术(ART)治疗早期宫颈癌患者的生殖和产科结局。
Gynecol Oncol. 2020 May;157(2):418-422. doi: 10.1016/j.ygyno.2020.02.016. Epub 2020 Feb 29.

引用本文的文献

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Trachelectomy and Cerclage Placement as Fertility-Sparing Surgery for Cervical Cancer-An Expert Survey.子宫颈切除术及宫颈环扎术作为宫颈癌保留生育功能手术的专家调查
J Pers Med. 2025 Feb 20;15(3):77. doi: 10.3390/jpm15030077.
2
Feasibility of the "cuff-sleeve" suture method in improving the uterine blood supply after radical trachelectomy: A retrospective analysis.“袖套式”缝合方法改善根治性宫颈切除术后子宫血供的可行性:一项回顾性分析
Gynecol Oncol Rep. 2024 Jun 18;54:101432. doi: 10.1016/j.gore.2024.101432. eCollection 2024 Aug.
3
Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review.
接受保留生育功能治疗的大于2厘米早期宫颈癌年轻女性的生殖结局:一项系统评价
Medicina (Kaunas). 2024 Apr 6;60(4):608. doi: 10.3390/medicina60040608.
4
Surgical, oncologic, and obstetric outcomes of radical trachelectomy in early-stage cervical cancer: results from a retrospective cohort study at Brazil National Cancer Institute.早期宫颈癌根治性气管切除术的外科、肿瘤学及产科结局:巴西国家癌症研究所一项回顾性队列研究的结果
Front Oncol. 2024 Mar 8;14:1267625. doi: 10.3389/fonc.2024.1267625. eCollection 2024.
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The Current Trend of Fertility Preservation in Patients with Cervical Cancer.宫颈癌患者生育力保存的当前趋势
Gynecol Minim Invasive Ther. 2023 Dec 7;13(1):4-9. doi: 10.4103/gmit.gmit_34_23. eCollection 2024 Jan-Mar.
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Fertility-sparing options for cancer patients.癌症患者的保留生育力选择。
Abdom Radiol (NY). 2023 May;48(5):1618-1628. doi: 10.1007/s00261-023-03839-8. Epub 2023 Mar 8.
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Fetal biometric and Doppler measurements following abdominal radical trachelectomy in the second trimester of the pregnancy.妊娠中期经腹广泛子宫切除术术后胎儿生物测量及多普勒测量。
BMC Pregnancy Childbirth. 2022 Apr 20;22(1):343. doi: 10.1186/s12884-022-04671-6.