Sato H, Kurata K, Yen Y H, Honjo I, Young Y H, Hsieh T
Department of Otolaryngology, Kyoto University, Japan.
Arch Otolaryngol Head Neck Surg. 1988 Aug;114(8):866-7. doi: 10.1001/archotol.1988.01860200050015.
In 35 patients with nasopharyngeal carcinoma that occupied the fossa of Rosenmüller, the relationship of the tumor, assessed by computed tomographic scans, to otitis media with effusion and ventilatory function of the eustachian tube was examined. Incidence of otitis media with effusion was low when the tumor was limited to the fossa of Rosenmüller (stage I), and high when the tumor extended from the fossa to the parapharyngeal space (stage II). Passive opening of the eustachian tube remained normal until the tumor occupied the parapharyngeal space (stage III). However, active tubal opening was impaired in stage I and the impairment increased with the tumor stage. These results indicate that tumor extension from the fossa of Rosenmüller to the parapharyngeal space and resultant poor active tubal opening cause the development of otitis media with effusion in patients with nasopharyngeal carcinoma.
在35例原发于咽隐窝的鼻咽癌患者中，通过计算机断层扫描评估肿瘤与中耳积液及咽鼓管通气功能的关系。当肿瘤局限于咽隐窝（I期）时，中耳积液的发生率较低；当肿瘤从咽隐窝扩展至咽旁间隙（II期）时，中耳积液的发生率较高。直到肿瘤占据咽旁间隙（III期）前，咽鼓管的被动开放功能仍保持正常。然而，在I期时咽鼓管的主动开放功能即已受损，且随着肿瘤分期的增加，这种损害也加重。这些结果表明，鼻咽癌患者中耳积液的发生是由于肿瘤从咽隐窝扩展至咽旁间隙，进而导致咽鼓管主动开放功能不良所致。
