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负压伤口疗法联合自体皮肤细胞悬液和网孔自体移植物的初步经验。

Initial Experience Combining Negative Pressure Wound Therapy With Autologous Skin Cell Suspension and Meshed Autografts.

机构信息

Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, District of Columbia, USA.

Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, District of Columbia, USA.

出版信息

J Burn Care Res. 2021 Aug 4;42(4):633-641. doi: 10.1093/jbcr/irab075.

Abstract

The success of autologous split-thickness skin grafts (STSGs) in the treatment of full-thickness burns is often dependent on the dressing used to secure it. Tie-over bolsters have been used traditionally; however, they can be uncomfortable for patients and preclude grafting large areas in one definitive operation. Negative pressure wound therapy (NPWT) is used as an alternative to bolster dressings and may afford additional wound healing benefits. In our center, NPWT has become the dressing of choice for securing STSGs. While the RECELL® system is being used in conjunction with STSGs, it is currently unknown whether autologous skin cell suspensions (ASCS) can be used with NPWT. This report is a retrospective chart review of nine patients treated in this manner. All wounds were almost completely re-epithelialized within 14 days, and their healing was as expected. Wound healing trajectories are shown. There were no significant complications in these patients. This dressing technique can be considered as an option when using ASCS and widely meshed STSG.

摘要

自体刃厚皮片(STSG)移植治疗全层烧伤的成功率通常取决于所使用的固定敷料。传统上使用过加压固定架;然而,它们可能会使患者感到不适,并且不能在一次确定性手术中移植大面积皮片。负压伤口治疗(NPWT)可作为加压固定架敷料的替代方法,并且可能提供额外的伤口愈合益处。在我们中心,NPWT 已成为固定 STSG 的首选敷料。虽然 RECELL®系统与 STSG 一起使用,但目前尚不清楚是否可以将自体皮肤细胞悬液(ASCS)与 NPWT 一起使用。本报告回顾性分析了以这种方式治疗的 9 例患者。所有伤口在 14 天内几乎完全再上皮化,愈合情况符合预期。显示了伤口愈合轨迹。这些患者没有出现明显的并发症。当使用 ASCS 和广泛网孔 STSG 时,可以考虑这种敷料技术作为一种选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e301/8335951/a6df40fd7dce/irab075f0001.jpg

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