He Y
Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine & College of Stomatology, Shanghai Jiao Tong University & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Shanghai Key Laboratory of Stomatology, Shanghai 200011.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2021 May 9;56(5):410-414. doi: 10.3760/cma.j.cn112144-20210122-00035.
Osteoradionecrosis of the jaw (ORNJ) is one of the most devastating complications caused by radiation therapy in head and neck region, which is among the greatest challenges within stomatology. Treatment methods have been enriched because of expanded understanding of the pathogenic mechanism of ORNJ. Meanwhile, the diagnosis and treatment of ORNJ have been uniformed and improved gradually in China, making progress on several aspects from the establishment of classification and hierarchy system and publication of the consensus on ORNJ treatment. In the present comment, the author reviewed the history and current situation of diagnosis and treatment of ORNJ and prospected the hot topics of basic, translational and clinical research.
颌骨放射性骨坏死（ORNJ）是头颈部放射治疗引起的最具破坏性的并发症之一，也是口腔医学面临的最大挑战之一。由于对ORNJ发病机制的认识不断深入，其治疗方法也日益丰富。同时，我国ORNJ的诊断和治疗也在逐步规范和完善，从分类分级体系的建立到ORNJ治疗共识的发布，在多个方面取得了进展。在本述评中，作者回顾了ORNJ诊断和治疗的历史与现状，并对基础、转化和临床研究的热点问题进行了展望。
