Dhiman Vikas, Menon Geetha R, Kaur Supreet, Mishra Amar, John Denny, Rao Vishnu Mendu Vardhan, Tiwari Rajnarayan R, Dhaliwal Rupinder Singh
ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, Madhya Pradesh, India.
ICMR-National Institute of Medical Statistics, New Delhi, India.
Neurol India. 2021 Mar-Apr;69(2):294-301. doi: 10.4103/0028-3886.314588.
There are wide variations reported in the prevalence rates of common neurological disorders in India leading to huge treatment gap. There is no comprehensive systematic review reporting prevalence of common neurological conditions affecting Indians which is essential for developing and aligning health services to meet patient care.
The aim of this study was to perform a systematic review and meta-analysis of prevalence of epilepsy, dementia, headache, and Parkinson's disease (PD) in India from 1980 to 2019.
We performed a bibliographic systematic search in PubMed and Google Scholar along with manual search for peer-reviewed cross-sectional studies and community-based surveys reporting prevalence of epilepsy, dementia, headache, and PD in India from January 1980 to July 2019. Meta-analysis was performed adopting a random-effects model using "Metafor" package in R.
The systematic review and meta-analysis included 50 studies [epilepsy (n = 22), dementia (n = 19), headache (n = 6), and PD (n = 3)] including a total of 179,1541 participants of which 5,890 were diagnosed with epilepsy, 1,843 with dementia, 914 with headache, and 121 were diagnosed with PD. The pooled prevalence of epilepsy was 4.7 per 1,000 population (95% CI: 3.8-5.6) with high heterogeneity (P < 0.01, I = 98%). The prevalence of dementia was found to be 33.7 per 1,000 population (95% CI: 19.4-49.8) (P = 0, I = 100%). The pooled prevalence of headache and PD were found to be 438.8 per 1,000 population (95% CI: 287.6-602.3) (P < 0.0001, I = 97.99%), and 0.8 per 1,000 population (95%CI: 0.4-1.3) (P < 0.01, I = 95%), respectively.
The findings could be used for appropriate policy measures and targeted treatments for addressing these conditions.
据报道，印度常见神经系统疾病的患病率差异很大，导致巨大的治疗缺口。目前尚无全面的系统综述报告影响印度人的常见神经系统疾病的患病率，而这对于制定和调整卫生服务以满足患者护理需求至关重要。
本研究的目的是对1980年至2019年印度癫痫、痴呆、头痛和帕金森病（PD）的患病率进行系统综述和荟萃分析。
我们在PubMed和谷歌学术上进行了文献系统检索，并手动搜索了1980年1月至2019年7月间报告印度癫痫、痴呆、头痛和PD患病率的同行评审横断面研究和基于社区的调查。采用R语言中的“Metafor”软件包，采用随机效应模型进行荟萃分析。
系统综述和荟萃分析纳入了50项研究[癫痫（n = 22）、痴呆（n = 19）、头痛（n = 6）和PD（n = 3）]，共1791541名参与者，其中5890人被诊断为癫痫，1843人被诊断为痴呆，914人被诊断为头痛，121人被诊断为PD。癫痫的合并患病率为每1000人4.7例（95%可信区间：3.8 - 5.6），异质性高（P < 0.01，I = 98%）。痴呆的患病率为每1000人33.7例（95%可信区间：19.4 - 49.8）（P = 0，I = 100%）。头痛和PD的合并患病率分别为每1000人438.8例（95%可信区间：287.6 - 602.3）（P < 0.0001，I = 97.99%）和每1000人0.8例（95%可信区间：0.4 - 1.3）（P < 0.01，I = 95%）。
这些研究结果可用于制定适当的政策措施和针对性治疗方案，以应对这些疾病。
