晚期帕金森病冻结步态的交错刺激
Interleaved Stimulation for Freezing of Gait in Advanced Parkinson's Disease.
作者信息
Zafar Syed M, Rajan Roopa, Krishnan Syam, Kesavapisharady Krishnakumar, Kishore Asha
机构信息
Department of Neurology, Saifee Hospital, Mumbai, Maharashtra, India.
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Neurol India. 2021 Mar-Apr;69(2):457-460. doi: 10.4103/0028-3886.314570.
BACKGROUND
Freezing of gait (FOG) is a disabling and refractory symptom of advanced Parkinson's disease (PD). Interleaved stimulation (ILS) is a novel paradigm which may benefit axial symptoms of PD.
OBJECTIVES
To assess the effect of ILS on FOG in patients unresponsive to conventional subthalamic nucleus (STN) stimulation.
METHODS
19 PD patients receiving subthalamic stimulation and experiencing FOG at both conventional (130-150Hz) and low frequency (60Hz) stimulation were given ILS.The primary outcome measure was the UPDRS part III gait score (item 29) at 3 months after ILS. A subset of patients was tested with the stand-walk-sit (SWS) test, 30 min after ILS.
RESULTS
The mean UPDRS part III gait score (baseline: 1.8 ± 0.6) improved at 30 min (1.1 ± 0.8, P = 0.017) and remained improved at 3 months (1.2 ± 0.8, P = 0.048). FOG episodes reduced during SWS test (P = 0.041).
CONCLUSIONS
ILS of STN through two adjacent contacts provided significant short-term beneficial effects on FOG.
背景
冻结步态（FOG）是晚期帕金森病（PD）的一种致残且难治的症状。交错刺激（ILS）是一种可能对PD的轴性症状有益的新范式。
目的
评估ILS对常规丘脑底核（STN）刺激无反应的患者的FOG的影响。
方法
19例接受丘脑底刺激且在常规（130 - 150Hz）和低频（60Hz）刺激时均出现FOG的PD患者接受了ILS。主要结局指标是ILS后3个月时的统一帕金森病评定量表（UPDRS）第三部分步态评分（第29项）。一部分患者在ILS后30分钟进行了站立 - 行走 - 坐下（SWS）测试。
结果
UPDRS第三部分平均步态评分（基线：1.8±0.6）在30分钟时改善（1.1±0.8，P = 0.017），并在3个月时仍保持改善（1.2±0.8，P = 0.048）。SWS测试期间FOG发作减少（P = 0.041）。
结论
通过两个相邻触点对STN进行ILS对FOG有显著的短期有益作用。
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