一例可能与IgG4相关疾病伴双侧视神经病变和双侧海马出血的病例。

A Case of Possible IgG4-Related Disease with Bilateral Optic Neuropathy and Bilateral Hippocampal Bleed.

作者信息

Gogineni Sujana, Mehta Anish, Shah Arjun Gaurang, Kumar Selva, Nagappa H H, Pradeep R, Javali Mahendra, Acharya Puroshottam, Srinivasa Rangasetty

机构信息

Department of Neurology, Ramaiah Institute of Neurosciences, Ramaiah Medical College and Hospitals, Bangalore, Karnataka, India.

Department of Medicine, Ramaiah Institute of Neurosciences, Ramaiah Medical College and Hospitals, Bangalore, Karnataka, India.

出版信息

Neurol India. 2021 Mar-Apr;69(2):484-486. doi: 10.4103/0028-3886.314517.

DOI:10.4103/0028-3886.314517

PMID:33904482

Abstract

IgG4-related disease (IgG4-RD) is a multisystem inflammatory disorder. The diagnosis requires consideration of clinical, radiographic, serological, and pathological evidence. Neurological involvement by IgG4-RD is relatively uncommon and is being increasingly recognized and reported with hypertrophic pachymeningitis and hypophysitis as the most frequent manifestations. IgG4-related involvement of brain parenchyma is rare, but isolated case reports exist. Here, we report a case of a young boy who presented to us with bilateral optic neuropathy and bilateral hippocampal bleed-related neurological involvement in a possible IgG4-RD, a rare entity.

摘要

IgG4相关性疾病（IgG4-RD）是一种多系统炎症性疾病。诊断需要综合考虑临床、影像学、血清学和病理学证据。IgG4-RD累及神经系统相对少见，目前其越来越多地被认识和报道，最常见的表现为肥厚性硬脑膜炎和垂体炎。IgG4相关性脑实质受累罕见，但有个别病例报道。在此，我们报告一例年轻男孩，其可能患有IgG4-RD（一种罕见疾病），表现为双侧视神经病变以及与双侧海马出血相关的神经系统受累。