Garcia M V, Martín-Barrientos J, Medina J M
Department of Biochemistry, Faculty of Pharmacy, University of Salamanca, Spain.
Biol Neonate. 1988;53(5):315-20. doi: 10.1159/000242807.
The concentrations of the major metabolites for nitrogen excretion and/or transport in maternal and fetal blood and amniotic fluid during the last 2 days of gestation were investigated. Alanine, glutamine, ammonia and allantoin accumulated in amniotic fluid during late gestation. Urea concentrations increased in amniotic fluid though only during the last day of gestation, suggesting that urea is taken up by the mother through the amniotic membranes. Glutamate did not accumulate in amniotic fluid during late gestation although high concentrations of it were found in fetal blood in the same circumstances, suggesting the occurrence of a mechanism for preventing fetal glutamate disposal.
对妊娠最后2天母体和胎儿血液及羊水中氮排泄和/或转运的主要代谢产物浓度进行了研究。妊娠后期，丙氨酸、谷氨酰胺、氨和尿囊素在羊水中蓄积。羊水中尿素浓度升高，不过仅在妊娠最后一天出现这种情况，这表明尿素通过羊膜被母体吸收。尽管在相同情况下胎儿血液中谷氨酸浓度很高，但妊娠后期羊水中谷氨酸并未蓄积，这表明存在一种防止胎儿谷氨酸排出的机制。
