State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.
Tongren Eye Center, Beijing Tongren Hospital, Capital Medical School, Beijing, 100730, China.
Int Ophthalmol. 2021 Sep;41(9):3087-3097. doi: 10.1007/s10792-021-01874-2. Epub 2021 Apr 27.
To describe a modified surgical approach with anterior vitrectomy, phacoemulsification (phaco) cataract extraction and irido-zonulo-hyaloid-vitrectomy (IZHV) in protracted acute angle closure crisis (AACC).
Non-comparative, retrospective case series including 21 eyes in 19 consecutive cases of protracted AACC, which persists for at least 7 days despite maximal medical and laser therapies, were included in this study. All patients underwent a modified surgical procedure with anterior vitrectomy, phaco cataract extraction, IOL implantation, goniosynechialysis (GSL) and IZHV, using modest phaco dynamic parameters with intraocular pressure (IOP) set at 30 mmHg through the procedure using Centurion® Vision System equipped with active fluidics while the anterior vitrectomy was set at 4000 or 5000 rpm. IOP and anterior chamber space were maintained through the procedure using ophthalmic viscosurgical device (OVD) injected through paracentesis whenever the Phaco or I/A probe was withdrawn from within the anterior chamber. Medical history, visual acuity (VA), IOP and anterior and posterior segment findings were recorded and compared before and after surgical treatment.
The average age of all patients was 60.05 years old, while the average period of persistent AACC was 20.05 days. Preoperatively, the average IOP of all included eyes was 44.40 ± 8.42 mmHg despite maximal topical and systemic anti-glaucoma medications and/or laser surgeries, while the average VA was 1.46 ± 0.88 (log MAR). Postoperatively, IOP was well controlled in all patients with an average IOP at 12.06 ± 3.07 mmHg without any anti-glaucoma medications at follow-ups, which was decreased significantly from that in preoperative measurements (P < 0.001). Visual acuity was improved significantly at final follow-up with an average postoperative VA at 0.74 ± 0.77 (log MAR, P < 0.001). Anterior segment inflammation was surprisingly mild with no or minimal inflammatory cells or exudates. Anterior segment configuration was resolved in all the cases. There was no recurrent IOP spike, anterior chamber shallowing or severe complications during an average follow-up of 5.38 months (ranging from 3 to 6 months).
Protracted AACC is a complex situation while a modified surgical strategy of anterior vitrectomy, phaco cataract extraction and IZHV provides a safe and efficient solution.
描述一种改良的手术方法,包括前玻璃体切割术、超声乳化白内障吸除术(phaco)和虹膜-睫状体-悬韧带-玻璃体切除术(IZHV),用于治疗迁延性急性闭角型青光眼(AACC)。
本研究纳入了 19 例 21 眼迁延性 AACC 患者,这些患者在经过最大剂量的药物和激光治疗后,至少持续 7 天仍处于急性发作期。所有患者均接受改良手术治疗,包括前玻璃体切割术、超声乳化白内障吸除术、人工晶状体植入术、房角分离术(GSL)和虹膜-睫状体-悬韧带-玻璃体切除术,术中采用温和的超声乳化参数,眼压(IOP)设定为 30mmHg,使用配备主动流体动力学的 Centurion® Vision System 进行操作,前玻璃体切割术转速设定为 4000 或 5000rpm。术中通过经皮穿刺注入眼用粘弹剂(OVD)以维持眼内压(IOP)和前房空间,当超声乳化或房角分离探针从前房撤出时,就进行该操作。记录并比较患者的手术前后的临床资料,包括病史、视力(VA)、IOP 和眼前段及眼后段检查结果。
所有患者的平均年龄为 60.05 岁,迁延性 AACC 的平均持续时间为 20.05 天。所有纳入眼术前平均 IOP 为 44.40±8.42mmHg,尽管给予了最大剂量的局部和全身降眼压药物治疗和/或激光手术,但平均 VA 为 1.46±0.88(logMAR)。术后,所有患者的 IOP 均得到良好控制,平均 IOP 为 12.06±3.07mmHg,随访期间无需使用任何降眼压药物,与术前相比显著降低(P<0.001)。最终随访时,视力显著提高,平均术后 VA 为 0.74±0.77(logMAR,P<0.001)。眼前段炎症反应较轻,仅有少量或无炎症细胞或渗出。所有病例的前节结构均得到恢复。在平均 5.38 个月(3 至 6 个月)的随访期间,未出现眼压再次升高、前房变浅或严重并发症。
迁延性 AACC 是一种复杂的情况,而改良的前玻璃体切割术、超声乳化白内障吸除术和虹膜-睫状体-悬韧带-玻璃体切除术的手术策略为这种情况提供了一种安全有效的治疗方法。