Khalid Hesham N, Abd El Gayed Eman M, Elrsool Asmaa M A, Bazid Heba A S
Dermatology and Andrology Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Medical Biochemistry Department, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
J Cosmet Dermatol. 2022 Mar;21(3):1185-1192. doi: 10.1111/jocd.14182. Epub 2021 May 12.
Orsomucoid protein A (ORM) is a major acute-phase protein. Serum ORM (se-ORM) protein A elevates in infections, malignancies, and autoimmune diseases. Urinary ORM (u-ORM) protein A is more accurate and less invasive marker of inflammation. Elevated u-ORM was associated with pathomechanism factors related to psoriasis such as endothelial dysfunction; however, the clinical significance of it has not been explored yet.
To evaluate se-ORM/u-ORM protein A and urinary orsomucoid protein A/urinary creatinine (u-ORM/u-CREAT) in patient with psoriasis and their relations to severity of the disease.
This case-control study was conducted at Dermatology and Andrology Department; 35 psoriasis patients and 35 age- and sex-matched healthy controls were included. They were subjected to history taking and general and dermatological examination. Psoriasis severity was assessed by Psoriasis Area and Severity Index (PASI) score. Measurement of se-ORM/u-ORM protein A using ELISA and u-ORM/u-CREAT using colorimetric method.
Highly significant difference between psoriasis patients and controls regarding u-ORM protein A level (p value = 0.01). It was also higher in severe cases than moderate and mild ones and higher in moderate than mild cases (p value 0.001, 0.001, and 0.004, respectively). There were significantly higher u-ORM/u-CREAT (p ˂ 0.001) levels in psoriasis patients than in controls. Also, significantly higher U-ORM/u-CREAT levels were found in severe psoriasis cases than in mild and moderate cases (p = 0.003 and 0.006, respectively). While the se-ORM levels showed no significant differences between the studied groups.
u-ORM/u-CREAT is a highly sensitive, easily available, and new inflammatory biomarker of psoriasis which correlates to the disease severity.
类胰蛋白酶原A（ORM）是一种主要的急性期蛋白。血清ORM（se-ORM）蛋白A在感染、恶性肿瘤和自身免疫性疾病中会升高。尿ORM（u-ORM）蛋白A是一种更准确且侵入性更小的炎症标志物。u-ORM升高与银屑病相关的病理机制因素如内皮功能障碍有关；然而，其临床意义尚未得到探索。
评估银屑病患者的se-ORM/u-ORM蛋白A和尿类胰蛋白酶原A/尿肌酐（u-ORM/u-CREAT）及其与疾病严重程度的关系。
本病例对照研究在皮肤科和男科进行；纳入35例银屑病患者和35例年龄及性别匹配的健康对照。对他们进行病史采集以及全身和皮肤科检查。采用银屑病面积和严重程度指数（PASI）评分评估银屑病严重程度。使用酶联免疫吸附测定法（ELISA）测量se-ORM/u-ORM蛋白A，使用比色法测量u-ORM/u-CREAT。
银屑病患者和对照组在u-ORM蛋白A水平上存在高度显著差异（p值 = 0.01）。在重度病例中也高于中度和轻度病例，在中度病例中高于轻度病例（p值分别为0.001、0.001和0.004）。银屑病患者的u-ORM/u-CREAT水平显著高于对照组（p ˂ 0.001）。此外，重度银屑病病例中的u-ORM/u-CREAT水平显著高于轻度和中度病例（分别为p = 0.003和0.006）。而se-ORM水平在研究组之间无显著差异。
u-ORM/u-CREAT是一种高度敏感、易于获取且与银屑病疾病严重程度相关的新型炎症生物标志物。
