Moustafa Yousry M, Elsaied Moustafa Ahmed, Abd-Elaaty Ehsan M, Elsayed Rasha A
Department of Dermatology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Indian J Dermatol. 2019 May-Jun;64(3):207-212. doi: 10.4103/ijd.IJD_420_17.
Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and it is a marker of nonspecific T-cell activation. Few studies have shown high levels of ADA in the epidermis and sera of psoriatic patients. Other inflammatory markers such as high-sensitive C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), and serum uric acid (SUA) have shown correlations with psoriasis area severity index (PASI) score. The correlation between ADA and PASI score is still a matter of debate.
The aim of this study was to evaluate serum ADA, hsCRP, SUA, and ESR in psoriatic patients and their correlation with PASI score.
This study included 60 psoriatic patients divided according to PASI score into three groups (mild, moderate, and severe) each containing 20 patients. PASI score <10 was defined as mild, (10-20) moderate, and >20 severe. Twenty healthy subjects of matched age and sex were included as control. Serum ADA, hsCRP, SUA, and ESR were evaluated for patients and controls. Correlations of ADA, hsCRP, SUA, and ESR with PASI scores were done.
While ADA, hsCRP, SUA, and ESR showed a significant increase in psoriatic patients compared with that of the controls (P<001), they showed no significant difference between different psoriatic groups (P>0.05) and no correlations with PASI score (P>0.05). The frequency of joint affection increased with increasing severity of psoriasis (5%, 10%, and 25% in mild, moderate, and severe psoriasis, respectively).
Serum ADA, hsCRP, SUA, and ESR showed higher levels among psoriatic patients than in controls. The increased ADA in psoriatic patients supports the role of T-cell activation and proliferative disorder in the pathogenesis of psoriasis. No significant correlations were found between these biomarkers and PASI score. Further studies are needed to validate these biomarkers as diagnostic and prognostic factors in psoriasis.
腺苷脱氨酶（ADA）是一种参与嘌呤代谢的酶，是非特异性T细胞活化的标志物。少数研究显示银屑病患者的表皮和血清中ADA水平较高。其他炎症标志物，如高敏C反应蛋白（hsCRP）、红细胞沉降率（ESR）和血清尿酸（SUA），已显示与银屑病面积严重程度指数（PASI）评分相关。ADA与PASI评分之间的相关性仍存在争议。
本研究旨在评估银屑病患者的血清ADA、hsCRP、SUA和ESR及其与PASI评分的相关性。
本研究纳入60例银屑病患者，根据PASI评分分为三组（轻度、中度和重度），每组20例。PASI评分<10定义为轻度，（10 - 20）为中度，>20为重度。纳入20名年龄和性别匹配的健康受试者作为对照。对患者和对照进行血清ADA、hsCRP、SUA和ESR评估。分析ADA、hsCRP、SUA和ESR与PASI评分的相关性。
与对照组相比，银屑病患者的ADA、hsCRP、SUA和ESR显著升高（P<0.01），但不同银屑病组之间无显著差异（P>0.05），且与PASI评分无相关性（P>0.05）。关节受累的频率随银屑病严重程度增加而升高（轻度、中度和重度银屑病患者中分别为5%、10%和25%）。
银屑病患者血清ADA、hsCRP、SUA和ESR水平高于对照组。银屑病患者ADA升高支持T细胞活化和增殖紊乱在银屑病发病机制中的作用。这些生物标志物与PASI评分之间未发现显著相关性。需要进一步研究以验证这些生物标志物作为银屑病诊断和预后因素的有效性。
