Diabetes & Obesity Program, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles, Los Angeles, CA
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Diabetes Care. 2021 Jun;44(6):1451-1453. doi: 10.2337/dc20-2733. Epub 2021 Apr 26.
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) on the incidence of new-onset type 2 diabetes and diabetic ketoacidosis (DKA) is unclear. It is unknown whether the coincidence of DKA noted in adult patients with type 2 diabetes is an issue for youth during the coronavirus disease 2019 pandemic.
A retrospective single-center medical record review was conducted in a large, urban children's hospital of pediatric subjects presenting with new-onset type 2 diabetes between March and August of 2018 to 2020.
The proportion of subjects presenting with new-onset type 2 diabetes in DKA dramatically increased in 2020 (9% in 2018, 3% in 2019, and 20% in 2020, = 0.029).
In 2020, youth with new-onset type 2 diabetes had a greater incidence of DKA at presentation than previously observed. Future studies should examine the impact of SARS-CoV2 exposure on the presentation of type 2 diabetes in all age-groups to inform better patient care.
严重急性呼吸综合征冠状病毒 2（SARS-CoV2）对新发 2 型糖尿病和糖尿病酮症酸中毒（DKA）发病率的影响尚不清楚。目前尚不清楚在 2019 年冠状病毒病大流行期间，2 型糖尿病成年患者中注意到的 DKA 合并症是否也是青少年的问题。
对一家大型城市儿童医院的儿科患者进行了回顾性单中心病历回顾，这些患者在 2018 年 3 月至 2020 年 8 月期间出现新发 2 型糖尿病。
2020 年新诊断为 2 型糖尿病患者中 DKA 的比例明显增加（2018 年为 9%，2019 年为 3%，2020 年为 20%， = 0.029）。
2020 年，新发 2 型糖尿病患者在就诊时 DKA 的发生率高于以往观察到的水平。未来的研究应检查 SARS-CoV2 暴露对所有年龄段 2 型糖尿病发病的影响，以为更好的患者护理提供信息。
