Chromosome Instability and Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
Chromosome Instability and Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.
Curr Biol. 2021 Apr 26;31(8):R386-R389. doi: 10.1016/j.cub.2021.02.014.
Microtubule attachments to kinetochores cause their deformation - a murky phenomenon known as intra-kinetochore stretching. A new study proposes that intra-kinetochore stretching is independent of microtubule-pulling forces and mediates efficient spindle assembly checkpoint silencing to prevent chromosomal instability.
微管与动粒的连接导致它们的变形——这是一种被称为动粒内拉伸的模糊现象。一项新的研究提出，动粒内拉伸不依赖于微管牵拉力，并介导有效的纺锤体组装检查点沉默，以防止染色体不稳定性。
