染色体不稳定性：拓展检验点沉默的作用。
Chromosomal instability: Stretching the role of checkpoint silencing.
机构信息
Chromosome Instability and Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
Chromosome Instability and Dynamics Group, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal; Cell Division Group, Experimental Biology Unit, Department of Biomedicine, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal.
出版信息
Curr Biol. 2021 Apr 26;31(8):R386-R389. doi: 10.1016/j.cub.2021.02.014.
Abstract
Microtubule attachments to kinetochores cause their deformation - a murky phenomenon known as intra-kinetochore stretching. A new study proposes that intra-kinetochore stretching is independent of microtubule-pulling forces and mediates efficient spindle assembly checkpoint silencing to prevent chromosomal instability.
摘要
微管与动粒的连接导致它们的变形——这是一种被称为动粒内拉伸的模糊现象。一项新的研究提出，动粒内拉伸不依赖于微管牵拉力，并介导有效的纺锤体组装检查点沉默，以防止染色体不稳定性。
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2
Prolonged mitosis causes separase deregulation and chromosome nondisjunction.有丝分裂时间过长会导致分离酶失活和染色体不分离。
Cell Rep. 2021 Jan 19;34(3):108652. doi: 10.1016/j.celrep.2020.108652.
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The Importance of Kinase-Phosphatase Integration: Lessons from Mitosis.激酶-磷酸酶整合的重要性：有丝分裂的启示。
Trends Cell Biol. 2018 Jan;28(1):6-21. doi: 10.1016/j.tcb.2017.09.005. Epub 2017 Oct 28.
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Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells.在紫杉醇处理的细胞中，未附着的动粒而非动粒内张力会阻止有丝分裂。
J Cell Biol. 2016 Feb 1;212(3):307-19. doi: 10.1083/jcb.201412139.
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