Department of Health, Medical and Neuropsychology, Leiden University, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; Department of Experimental Psychology, Ghent University, Ghent, Belgium.
Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.
Neurosci Biobehav Rev. 2021 Aug;127:158-170. doi: 10.1016/j.neubiorev.2021.04.023. Epub 2021 Apr 24.
Parkinson's disease (PD) is a neurological disorder associated primarily with overt motor symptoms. Several studies show that PD is additionally accompanied by impairments in covert cognitive processes underlying goal-directed motor functioning (e.g., action planning, conflict adaptation, inhibition), and that dopaminergic medication may modulate these action control components. In this review we aim to leverage findings from studies in this domain to elucidate the role of dopamine (DA) in action control. A qualitative review of studies that investigated the effects of medication status (on vs. off) on action control in PD suggests a component-specific role for DA in action control, although the expression of medication effects depends on characteristics of both the patients and experimental tasks used to measure action control. We discuss these results in the light of findings from other research lines examining the role of DA in action control (e.g., animal research, pharmacology), and recommend that future studies use multi-method, within-subject approaches to model DA effects on action control across different components as well as underlying striatal pathways (ventral vs. dorsal).
帕金森病（PD）是一种主要与明显运动症状相关的神经疾病。有几项研究表明，PD 还伴随着目标导向运动功能（如动作规划、冲突适应、抑制）背后的隐性认知过程受损，而多巴胺能药物可能调节这些动作控制成分。在这篇综述中，我们旨在利用该领域研究的结果来阐明多巴胺（DA）在动作控制中的作用。对研究药物状态（开或关）对 PD 患者动作控制影响的研究进行定性综述表明，DA 在动作控制中具有特定的作用，但药物作用的表现取决于患者的特征和用于测量动作控制的实验任务。我们根据其他研究线（例如动物研究、药理学）中检查 DA 在动作控制中的作用的结果讨论了这些结果，并建议未来的研究使用多方法、个体内的方法来模拟 DA 对不同成分以及潜在纹状体通路（腹侧与背侧）的动作控制的影响。
