Bykovskaia S N, Blokhina N G, Speranskiĭ D L, Kuprianova T A
Biull Eksp Biol Med. 1988 Jun;105(6):708-9.
The analysis of cytotoxic activity of platelets from patients with lung cancer is presented. It has been shown that these platelets lyse fresh isolated autological and allogenic tumor cells in 38.5% of cases and lyse the cells in the culture of lung adenocarcinoma cell line in 82.4% of cases, while platelets from healthy donors do not lyse fresh isolated and cultured cells of lung cancer. Cytotoxicity of platelets from patients and control subjects against HeLa and K 562 was identical and did not exceed 10%. The platelets from healthy controls, unlike platelets from patients with lung cancer, lysed tumor cells of melanoma cultured cell line Mel 1. Thus, it has been shown for the first time that platelets from the peripheral blood of patients with lung cancer have specific antitumor activity.
本文呈现了对肺癌患者血小板细胞毒性活性的分析。结果显示，这些血小板在38.5%的病例中可裂解新鲜分离的自体和异体肿瘤细胞，在82.4%的病例中可裂解肺腺癌细胞系培养物中的细胞，而健康供者的血小板不会裂解新鲜分离和培养的肺癌细胞。患者和对照受试者的血小板对HeLa和K 562的细胞毒性相同，且不超过10%。与肺癌患者的血小板不同，健康对照者的血小板可裂解黑色素瘤培养细胞系Mel 1的肿瘤细胞。因此，首次证明肺癌患者外周血中的血小板具有特异性抗肿瘤活性。
