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[恢复进食后大鼠脑外侧下丘脑区神经元的细胞内再生]

[Intracellular regeneration of neurons in the rat lateral hypothalamic area of the brain after resumption of food intake].

作者信息

Abushov B M, Verbitskaia L B

出版信息

Biull Eksp Biol Med. 1988 Jun;105(6):734-6.

PMID:3390594
Abstract

Electron microscopy was used to explore changes in intracellular regeneration processes in neurons of the anterior, medial and posterior parts of the lateral hypothalamus area (LHA) of rats at various time (10, 20, 30, 50 and 70 days) after resumption of food perception. Ultrastructural changes observed during 7 days of food deprivation in intact neurons were of a reversible character. Recovery processes initially appeared and finished earlier in the neurons of medial (day 30) and anterior (day 50) parts of the LHA, in the posterior part of LHA the normalization of the neuronal structure was slower and was over only by the 70th day after the resumption of food reception. The above data are both of theoretical and practical importance, serving as a base for the study of directed treatment of diseases caused by hunger.

摘要

采用电子显微镜观察大鼠下丘脑外侧区(LHA)前、中、后部分神经元在恢复食物感知后的不同时间点(10、20、30、50和70天)细胞内再生过程的变化。在完整神经元中,观察到的7天禁食期间的超微结构变化具有可逆性。LHA中部(第30天)和前部(第50天)的神经元中,恢复过程最初出现并较早完成,LHA后部神经元结构的正常化较慢,仅在恢复食物摄入后第70天才完成。上述数据具有理论和实际意义,为研究饥饿引起疾病的定向治疗奠定了基础。

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