Cardiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Cardiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Clin Investig Arterioscler. 2021 Nov-Dec;33(6):282-288. doi: 10.1016/j.arteri.2021.02.008. Epub 2021 Apr 24.
To assess the relationship between vitamin D deficiency and severity of coronary artery disease using multislice CT coronary angiography.
100 patients diagnosed with coronary artery disease during multislice CT coronary angiography were subjected to full evaluation of coronary artery disease severity followed by measurement of serum vitamin D level.
The mean value of serum vitamin D level was 13.35±7.49ng/ml. 76% of the patients had vitamin D deficiency (<20ng/ml). 41% of the patients had single vessel disease, 28% had two vessel diseases, and 31% had multi-vessel disease. Patients with vitamin D deficiency had higher degree of coronary stenosis, higher coronary Ca score (p<0.001) and higher number of affected vessels compared with normal vitamin D level subgroup (p<0.001). Vitamin D level showed a significant negative correlations with age (r=-0.290, p=0.003), coronary Ca score (r=-0.630, p<0.001) and severity of coronary lesions. Multivariate linear regression analysis showed that dyslipidemia and vitamin D level were independent predictors of percent severity of coronary stenosis.
In addition to traditional cardiovascular risk factors, vitamin D deficiency looks to be independent predictor of coronary artery disease severity including percent stenosis, number of the affected vessels as well as degree of coronary calcification.
应用多层 CT 冠状动脉造影评估维生素 D 缺乏与冠状动脉疾病严重程度的关系。
对 100 例行多层 CT 冠状动脉造影诊断为冠状动脉疾病的患者进行冠状动脉疾病严重程度的全面评估，并检测血清维生素 D 水平。
血清维生素 D 水平的平均值为 13.35±7.49ng/ml。76%的患者存在维生素 D 缺乏（<20ng/ml）。41%的患者单支血管病变，28%的患者双支血管病变，31%的患者多支血管病变。与维生素 D 水平正常亚组相比，维生素 D 缺乏患者的冠状动脉狭窄程度更高，冠状动脉钙评分更高（p<0.001），病变血管数更多（p<0.001）。维生素 D 水平与年龄（r=-0.290，p=0.003）、冠状动脉钙评分（r=-0.630，p<0.001）和冠状动脉病变严重程度呈显著负相关。多元线性回归分析显示，血脂异常和维生素 D 水平是冠状动脉狭窄严重程度的独立预测因子。
除了传统的心血管危险因素外，维生素 D 缺乏似乎也是冠状动脉疾病严重程度的独立预测因子，包括狭窄程度、病变血管数以及冠状动脉钙化程度。
