癫痫中的多重障碍机制与血脑屏障：糖皮质激素受体-热休克蛋白对药物调控的作用 - Suppr

Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

作者信息

Achar Aneesha, Ghosh Chaitali

机构信息

Cerebrovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Cerebrovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic; Department of Biomedical Engineering and Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

出版信息

Neural Regen Res. 2021 Dec;16(12):2427-2428. doi: 10.4103/1673-5374.313046.

DOI:10.4103/1673-5374.313046

PMID:33907029

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8374577/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19b5/8374577/a9e8066352e6/NRR-16-2427-g001.jpg

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Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

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Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy.

Mol Neurobiol. 2020 Nov;57(11):4511-4529. doi: 10.1007/s12035-020-02043-9. Epub 2020 Aug 3.

Detrimental effects of hypercortisolism on brain structure and related risk factors.

Sci Rep. 2020 Jul 29;10(1):12708. doi: 10.1038/s41598-020-68166-0.

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks.

Mol Syst Biol. 2020 Jul;16(7):e9510. doi: 10.15252/msb.20209510.

Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.

Drug Discov Today. 2020 Jan;25(1):89-106. doi: 10.1016/j.drudis.2019.09.009. Epub 2019 Sep 18.

Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.

Mol Neurobiol. 2019 Dec;56(12):8392-8407. doi: 10.1007/s12035-019-01673-y. Epub 2019 Jun 26.

The Roof is Leaking and a Storm is Raging: Repairing the Blood-Brain Barrier in the Fight Against Epilepsy.

Epilepsy Curr. 2019 May-Jun;19(3):177-181. doi: 10.1177/1535759719844750. Epub 2019 Apr 30.

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Epilepsia. 2018 Nov;59(11):2049-2060. doi: 10.1111/epi.14567. Epub 2018 Sep 28.

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.

Epilepsia. 2017 Apr;58(4):576-585. doi: 10.1111/epi.13703. Epub 2017 Feb 15.

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.

Epilepsia. 2014 Aug;55(8):1255-63. doi: 10.1111/epi.12713. Epub 2014 Jul 3.

Glucocorticoid receptor signaling in health and disease.

Trends Pharmacol Sci. 2013 Sep;34(9):518-30. doi: 10.1016/j.tips.2013.07.003. Epub 2013 Aug 14.

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Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

作者信息

Achar Aneesha, Ghosh Chaitali

机构信息

Cerebrovascular Research, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

出版信息

Neural Regen Res. 2021 Dec;16(12):2427-2428. doi: 10.4103/1673-5374.313046.

DOI:10.4103/1673-5374.313046

PMID:33907029

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8374577/

Abstract

摘要

相似文献

Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

Neural Regen Res. 2021 Dec;16(12):2427-2428. doi: 10.4103/1673-5374.313046.

Glucocorticoid receptor and heat shock factor 1: novel mechanism of reciprocal regulation.

Vitam Horm. 2005;71:239-62. doi: 10.1016/S0083-6729(05)71008-6.

Pattern of heat shock factor and heat shock protein expression in lymphocytes of bipolar patients: increased HSP70-glucocorticoid receptor heterocomplex.

J Psychiatr Res. 2013 Nov;47(11):1725-36. doi: 10.1016/j.jpsychires.2013.07.018. Epub 2013 Aug 9.

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

J Biol Chem. 1992 Jan 5;267(1):17-20.

Effects of thermal stress on the expression of glucocorticoid receptor complex linked genes in Senegalese sole (Solea senegalensis): Acute and adaptive stress responses.

Gen Comp Endocrinol. 2017 Oct 1;252:173-185. doi: 10.1016/j.ygcen.2017.06.022. Epub 2017 Jun 23.

Glucocorticoids modulate the synthesis and expression of a 72 kDa heat shock protein in cultured Graves' retroocular fibroblasts.

Acta Endocrinol (Copenh). 1993 Jan;128(1):41-50. doi: 10.1530/acta.0.1280041.

Heat shock protein-27 is upregulated in the temporal cortex of patients with epilepsy.

Epilepsia. 2004 Dec;45(12):1549-59. doi: 10.1111/j.0013-9580.2004.14904.x.

Isoform composition and stoichiometry of the approximately 90-kDa heat shock protein associated with glucocorticoid receptors.

J Biol Chem. 1988 May 15;263(14):6695-702.

Relationship between the induction of heat shock proteins and the decrease in glucocorticoid receptor during heat shock response in human osteosarcoma cells.

Sci China B. 1995 Dec;38(12):1473-81.

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Epilepsia. 2018 Nov;59(11):2049-2060. doi: 10.1111/epi.14567. Epub 2018 Sep 28.

引用本文的文献

Overview of Metformin and Neurodegeneration: A Comprehensive Review.

Pharmaceuticals (Basel). 2025 Mar 28;18(4):486. doi: 10.3390/ph18040486.

The role of molecular chaperones in the mechanisms of epileptogenesis.

Cell Stress Chaperones. 2023 Nov;28(6):599-619. doi: 10.1007/s12192-023-01378-1. Epub 2023 Sep 27.

Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.

Neural Regen Res. 2023 Aug;18(8):1763-1769. doi: 10.4103/1673-5374.360263.

Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel.

Neural Regen Res. 2023 Mar;18(3):594-602. doi: 10.4103/1673-5374.350206.

Drug Delivery Challenges in Brain Disorders across the Blood-Brain Barrier: Novel Methods and Future Considerations for Improved Therapy.

Biomedicines. 2021 Dec 4;9(12):1834. doi: 10.3390/biomedicines9121834.

本文引用的文献

Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy.

Mol Neurobiol. 2020 Nov;57(11):4511-4529. doi: 10.1007/s12035-020-02043-9. Epub 2020 Aug 3.

Detrimental effects of hypercortisolism on brain structure and related risk factors.

Sci Rep. 2020 Jul 29;10(1):12708. doi: 10.1038/s41598-020-68166-0.

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks.

Mol Syst Biol. 2020 Jul;16(7):e9510. doi: 10.15252/msb.20209510.

Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.

Drug Discov Today. 2020 Jan;25(1):89-106. doi: 10.1016/j.drudis.2019.09.009. Epub 2019 Sep 18.

Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.

Mol Neurobiol. 2019 Dec;56(12):8392-8407. doi: 10.1007/s12035-019-01673-y. Epub 2019 Jun 26.

The Roof is Leaking and a Storm is Raging: Repairing the Blood-Brain Barrier in the Fight Against Epilepsy.

Epilepsy Curr. 2019 May-Jun;19(3):177-181. doi: 10.1177/1535759719844750. Epub 2019 Apr 30.

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Epilepsia. 2018 Nov;59(11):2049-2060. doi: 10.1111/epi.14567. Epub 2018 Sep 28.

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.

Epilepsia. 2017 Apr;58(4):576-585. doi: 10.1111/epi.13703. Epub 2017 Feb 15.

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures.

Epilepsia. 2014 Aug;55(8):1255-63. doi: 10.1111/epi.12713. Epub 2014 Jul 3.

Glucocorticoid receptor signaling in health and disease.

Trends Pharmacol Sci. 2013 Sep;34(9):518-30. doi: 10.1016/j.tips.2013.07.003. Epub 2013 Aug 14.

Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

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Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

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