Graduate School of Health Sciences, Yamagata Prefectural University of Health Sciences, Yamagata, Japan.
Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Clin Interv Aging. 2021 Apr 19;16:645-653. doi: 10.2147/CIA.S296981. eCollection 2021.
Ultrasound elastography has been used to evaluate the skeletal muscle stiffness as a biomarker for sarcopenia assessment. However, there is no consensus with respect to the size and location of the region of interest in assessing such fat infiltrated muscle. The objective of this study was to determine which cross-sectional area should be measured in torn disuse muscle with fat infiltration to accurately measure muscle activity using real-time tissue elastography (RTE).
Twenty-seven patients, whose rotator cuff muscle with torn tendon was successfully repaired, were followed by programmed rehabilitation. RTE measurements of the supraspinatus muscle were obtained during muscle contraction before and one-year after surgery so that the activity value was defined as the difference between elastography measurements at rest and elastography measurements during contraction. Given that the patients with successfully repaired and completed rehabilitation showed an increased activity value, the sensitivity for three regions of interest; posterior portion of the anterior-middle subregion (AM-p), anterior region (AR), and whole cross-sectional area of the supraspinatus (whole) were compared with the number of patients showing an increase in activity values as sensitivity analysis.
The sensitivity showing an increase in activity values was 74.1% for the AM-p area, 70.4% for the AR area, and 81.5% for the whole area. Intraclass correlation coefficient was 0.87-0.97 for the AM-p area, 0.88-0.98 for the AR area and 0.92-0.99 for the whole area.
The whole cross-sectional area is suitable to measure muscle activity in muscle with fat infiltration. The results in this study will provide some beneficial information when ultrasound elastography is used for the assessment of sarcopenia muscle with fat infiltration.
超声弹性成像已被用于评估骨骼肌僵硬度，作为肌少症评估的生物标志物。然而，在评估这种脂肪浸润肌肉时，对于感兴趣区域的大小和位置尚未达成共识。本研究的目的是确定在撕裂性废用性肌肉伴脂肪浸润中应测量哪个横截面积，以便使用实时组织弹性成像（RTE）准确测量肌肉活动。
对 27 例成功修复肩袖撕裂肌腱的患者进行了程序性康复治疗。在术前和术后 1 年，对冈上肌进行 RTE 测量，以便将活动值定义为静息时和收缩时弹性成像测量值之间的差值。由于成功修复并完成康复的患者显示出活动值增加，因此对三个感兴趣区域（前中份后区（AM-p）、前区（AR）和冈上肌的整个横截面积（whole））的敏感度与显示活动值增加的患者数量进行了比较。
AM-p 区域、AR 区域和整个冈上肌区域的活动值增加的敏感度分别为 74.1%、70.4%和 81.5%。AM-p 区域、AR 区域和整个冈上肌区域的组内相关系数分别为 0.87-0.97、0.88-0.98 和 0.92-0.99。
整个横截面积适用于测量脂肪浸润肌肉的肌肉活动。本研究的结果将为使用超声弹性成像评估脂肪浸润性肌少症肌肉提供有益信息。
