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多米尼加共和国的血管性轻度认知障碍及其与糖化血红蛋白水平和载脂蛋白E基因型的关系。

Vascular mild cognitive impairment and its relationship to hemoglobin A1c levels and apolipoprotein E genotypes in the Dominican Republic.

作者信息

Medrano Martin, Castro-Tejada Gelanys, Lantigua Rafael, Silvestre Gretel, Diaz Sergio, Mota Patricia, Diaz-Garelli Franck

机构信息

School of Medicine, Pontificia Universidad Católica Madre y Maestra - Santiago, Dominican Republic.

Biomedical and Clinical Research Center, Hospital Universitario José Maria Cabral y Baez - Santiago, Dominican Republic.

出版信息

Dement Neuropsychol. 2021 Jan-Mar;15(1):69-78. doi: 10.1590/1980-57642021dn15-010007.

DOI:10.1590/1980-57642021dn15-010007
PMID:33907599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8049571/
Abstract

UNLABELLED

Dementia and vascular mild cognitive impairment (VaMCI) currently impose a tremendous human and economic burden on patients from aging populations and their families worldwide. Understanding the interplay of cardiometabolic risk factors and apolipoprotein E (APOE) may direct us to a more personalized medicine and preventative care in MCI and dementia.

OBJECTIVE

To evaluate the relationship of cardiometabolic risk factors with MCI and assess the APOE genotype's role in an elderly cohort in the Dominican Republic.

METHODS

We studied a cohort of 180 participants 65 years of age and older using a combined assessment of cardiometabolic risk factors, neuropsychological battery tests, and APOE genotyping. We used the number of failed tests as a proxy to predict MCI.

RESULTS

We found that patients with the ε3-ε4 APOE genotype had 2.91 higher number of failed cognitive tests (p=0.027) compared to patients with the ε3-ε3 genotyped. The rate of test failures increased 10% (p=0.025) per unit increase in HbA1c percentage.

CONCLUSIONS

Increased Hemoglobin A1c levels and ε3-ε4 APOE genotypes seem to have an association with the development of VaMCI.

摘要

未标注

痴呆症和血管性轻度认知障碍（VaMCI）目前给全球老龄化人口中的患者及其家庭带来了巨大的人力和经济负担。了解心脏代谢危险因素与载脂蛋白E（APOE）之间的相互作用，可能会引导我们在MCI和痴呆症方面实现更个性化的医学和预防保健。

目的

评估多米尼加共和国老年队列中心脏代谢危险因素与MCI的关系，并评估APOE基因型的作用。

方法

我们对180名65岁及以上的参与者进行了队列研究，综合评估心脏代谢危险因素、神经心理成套测试和APOE基因分型。我们将测试未通过的数量作为预测MCI的指标。

结果

我们发现，与ε3-ε3基因型患者相比，ε3-ε4 APOE基因型患者的认知测试未通过数量高出2.91倍（p=0.027）。糖化血红蛋白（HbA1c）百分比每增加一个单位，测试未通过率就增加10%（p=0.025）。

结论

糖化血红蛋白水平升高和ε3-ε4 APOE基因型似乎与VaMCI的发生有关。