O'Hara R, Yesavage J A, Kraemer H C, Mauricio M, Friedman L F, Murphy G M
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California, USA.
J Am Geriatr Soc. 1998 Dec;46(12):1493-8. doi: 10.1111/j.1532-5415.1998.tb01532.x.
This study investigated whether the Apolipoprotein (APOE) epsilon4 allele was associated with cognitive decline in community-dwelling older adults.
Longitudinal cognitive performance of older adults with the epsilon3/epsilon4 genotype was compared with that of older adults with the epsilon3/epsilon3 genotype.
Aging Clinical Research Center, Stanford University.
One hundred community-dwelling older adults were recruited from a pool of 531 individuals who had participated in a memory training study 4 to 5 years earlier. These individuals were concerned about their memory functioning and were recruited through newspaper advertisements and contacts with local senior centers. The 100 individuals who agreed to participate in the follow-up investigation were between 59 and 95 years of age.
At both baseline and follow-up, subjects were administered a battery of seven cognitive tests that examined verbal and spatial memory, attention, speed-of-processing, and language abilities. APOE genotype was determined at follow-up.
Individuals with the epsilon3/epsilon4 APOE genotype were significantly younger than individuals with the APOE epsilon3/epsilon3 genotype. No significant differences were observed between the two groups on measures of attention, speed-of-processing, vocabulary, immediate verbal memory, and immediate spatial memory. However, those older adults with the epsilon3/epsilon4 genotype exhibited significantly greater decline in performance on delayed recall of verbal material than did those with the epsilon3/epsilon3 APOE genotype.
These findings are consistent with previous studies, which suggest that the APOE epsilon4 allele predicts decline on measures of delayed recall.
本研究调查了载脂蛋白（APOE）ε4等位基因是否与社区居住的老年人认知能力下降有关。
将ε3/ε4基因型老年人的纵向认知表现与ε3/ε3基因型老年人的进行比较。
斯坦福大学衰老临床研究中心。
从531名4至5年前参与记忆训练研究的个体中招募了100名社区居住的老年人。这些个体担心自己的记忆功能，通过报纸广告和与当地老年中心联系招募而来。同意参与后续调查的100名个体年龄在59至95岁之间。
在基线和随访时，对受试者进行了一系列七项认知测试，以检查言语和空间记忆、注意力、处理速度和语言能力。随访时确定APOE基因型。
ε3/ε4 APOE基因型个体比APOE ε3/ε3基因型个体明显年轻。两组在注意力、处理速度、词汇、即时言语记忆和即时空间记忆测量方面未观察到显著差异。然而，ε3/ε4基因型的老年人在言语材料延迟回忆方面的表现下降幅度明显大于APOE ε3/ε3基因型的老年人。
这些发现与先前的研究一致，表明APOE ε4等位基因预示着延迟回忆测量指标的下降。
