与腺病毒载体疫苗相关的肝素诱导的血小板减少症样综合征是与疫苗本身有关，还是与针对严重急性呼吸综合征冠状病毒2的自身免疫反应有关：来自既往感染病例报告的见解与启示？
Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
作者信息
AbdelMassih A, Hozaien R, El Shershaby M, Kamel A, Ismail H-A, Fouda R
机构信息
Paediatric Cardiology Unit, Paediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Paediatric Cardio-Oncology Department, Children Cancer Hospital of Egypt, Cairo, Egypt.
出版信息
New Microbes New Infect. 2021 May;41:100884. doi: 10.1016/j.nmni.2021.100884. Epub 2021 Apr 23.
Prothrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in the management of implicated cases.
在接种ChAdOx疫苗的受种者中出现的血栓前状态，类似于肝素诱导的血小板减少症（HIT），这在国际上敲响了警钟。在2019冠状病毒病的几例病例报告中详细描述了类似HIT的发作情况。这表明存在共同的发病机制，因此有必要改变对相关病例的管理方式。
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