Bernard D, Morgan S, Tassé D, Wassef R
Du département de chirurgie, Université de Montréal, Hôpital Saint-Luc, PQ.
Can J Surg. 1988 Jul;31(4):239-42.
The management of patients with endoscopically removed malignant intestinal polyps is controversial. The risk of residual disease should be assessed against the risk of a surgical operation. The authors report 35 cases of malignant polyps (5.5% of 641 colonoscopically removed adenomas). Sixteen patients had carcinoma in situ and received no further treatment and 19 had invasive carcinoma (sessile in 6, pedunculated in 13). Of these 19, 7 did not undergo surgery--because of old age in 2, minimal invasion in 3, a low rectal location in 1 and refusal in 1. Twelve patients (3 with sessile, 9 with pedunculated polyps) underwent a surgical resection, and residual disease was present in 3 (25%), 1 with positive nodes. Reported criteria of increased risk of residual disease--cancer in lymphatics or veins, incomplete excision, tumour at resection margin, sessile and villous tumours--were present in nine. All three patients with residual disease had microscopically involved margins of resection. The authors believe that the increased risk of recurrence justifies the risk associated with subsequent surgical resection unless the patient is otherwise a poor operative risk.
经内镜切除的恶性肠息肉患者的管理存在争议。应根据手术风险评估残留疾病的风险。作者报告了35例恶性息肉(占641例经结肠镜切除腺瘤的5.5%)。16例原位癌患者未接受进一步治疗,19例为浸润性癌(6例无蒂,13例有蒂)。在这19例患者中,7例未接受手术——2例因年龄较大,3例因浸润程度轻微,1例因直肠低位,1例因拒绝手术。12例患者(3例无蒂息肉,9例有蒂息肉)接受了手术切除,3例(25%)存在残留疾病,1例伴有阳性淋巴结。9例患者存在报告中提及的残留疾病风险增加的标准——淋巴管或静脉内癌、切除不完全、切缘肿瘤、无蒂和绒毛状肿瘤。所有3例残留疾病患者的切除边缘在显微镜下均有累及。作者认为,除非患者手术风险极高,否则复发风险增加证明后续手术切除的风险是合理的。