Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Exp Pharmacol Physiol. 2021 Aug;48(8):1059-1069. doi: 10.1111/1440-1681.13510. Epub 2021 May 24.
Studies investigating the effects of spirulina on inflammation and oxidative stress status are controversial. Therefore, the current systematic review and meta-analysis aimed to evaluate the impacts of spirulina supplementation on oxidative stress indicators and inflammatory markers. PubMed-Medline, SCOPUS, Web of Science, Embase databases and Google Scholar were searched up to 1 October 2020. Random-effect analysis was applied to perform meta-analysis. Subgroup analyses and multivariate meta-regression were performed to find heterogeneity sources. Quality assessment was conducted using Cochrane Collaboration's tool. A total of 11 studies that enrolled 465 subjects were included in our meta-analysis. Pooled results demonstrated a significant increase in interleukin-2 (IL-2) concentrations [Standardized mean difference (SMD = 2.69 pg/mL; 95% CI: 0.26, 5.11; P = .03)]; however this result changed to insignificant (SMD = 0.54 pg/mL; 95% CI: -1.29, 2.27; P > .05) when sensitivity analysis performed. A marginal decreasing effect were also found on interleukin-6 (IL-6) (SMD = -0.72 mg/dL; 95% CI: -1.50, 0.07; P = .073) and thiobarbituric acid reactive substances (TBARS) levels (SMD = -0.65; 95% CI: -1.37, 0.08; P = .08). In addition, results of subgroup analysis revealed a significant reduction in IL-6 and TBARS concentrations when the baseline body mass index (BMI) of participants was lower than 25 kg/m . Moreover, spirulina had no significant effect on tumour necrosis factor-α (TNF-α) (SMD = -0.07 mg/dL; 95% CI: -0.33, 0.18; P = .56) and malondialdehyde (MDA) concentrations (SMD = -0.42; 95% CI: -0.98, 0.14; P = .14). Spirulina consumption contributed to a significant increase in IL-2 concentrations changing to insignificant after sensitivity analysis and marginal decreasing effects on IL-6 and TBARS levels. No considerable impacts were observed on TNF-α and MDA concentrations.
研究表明，螺旋藻对炎症和氧化应激状态的影响存在争议。因此，本系统评价和荟萃分析旨在评估螺旋藻补充剂对氧化应激指标和炎症标志物的影响。检索了 PubMed-Medline、SCOPUS、Web of Science、Embase 数据库和 Google Scholar，截至 2020 年 10 月 1 日。采用随机效应分析进行荟萃分析。进行亚组分析和多元荟萃回归以寻找异质性来源。使用 Cochrane 协作工具进行质量评估。我们的荟萃分析共纳入了 11 项研究，共纳入 465 名受试者。汇总结果表明，白细胞介素-2（IL-2）浓度显著增加[标准化均数差（SMD=2.69pg/mL；95%CI：0.26，5.11；P=0.03)]；然而，当进行敏感性分析时，结果变为无统计学意义（SMD=0.54pg/mL；95%CI：-1.29，2.27；P>.05）。也发现白细胞介素-6（IL-6）（SMD=-0.72mg/dL；95%CI：-1.50，0.07；P=0.073）和硫代巴比妥酸反应物质（TBARS）水平（SMD=-0.65；95%CI：-1.37，0.08；P=0.08）有边际降低的作用。此外，亚组分析结果表明，当参与者的基线体重指数（BMI）低于 25kg/m 时，IL-6 和 TBARS 浓度显著降低。此外，螺旋藻对肿瘤坏死因子-α（TNF-α）（SMD=-0.07mg/dL；95%CI：-0.33，0.18；P=0.56）和丙二醛（MDA）浓度（SMD=-0.42；95%CI：-0.98，0.14；P=0.14）没有显著影响。螺旋藻的摄入导致白细胞介素-2 浓度显著增加，在敏感性分析后变为无统计学意义，对白细胞介素-6 和 TBARS 水平有轻微降低作用。对 TNF-α和 MDA 浓度没有明显影响。
