Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, USA.
J Dermatol. 2021 Aug;48(8):1193-1200. doi: 10.1111/1346-8138.15907. Epub 2021 Apr 27.
Dermoscopic images of pigmented lesions have distinct features on the sole where skin ridges and furrows exist. Pigmentation of benign nevus usually locates on the skin furrow, while the malignant melanoma is pigmented on the skin ridge. Correspondence between dermoscopy and pathology in the pigmented lesions on soles have been studied based on conventional vertical pathological images. However, for the full understanding of the correspondence, observation of horizontal histological images would be required, because the epidermis constructs unique horizontal structures, namely crista profunda limitans, crista profunda intermedia, and transverse ridge. In this study, we analyzed basic dermoscopic images of the representative acral melanocytic lesions (nevus, lentigo, and malignant melanoma) by horizonal histological images. We created serial horizontal pathological images by digital reconstruction of a hundred of serial vertical images. We could show that parallel furrow pattern is created by the pigmentation of crista profunda limitans, parallel ridge pattern by the pigmentation of both of crista profunda limitans and crista profunda intermediate, and lattice-like pattern by the pigmentation of transverse ridge. Our results would be useful for the intuitive histological understanding of dermoscopy.
足底色素病变的皮肤纹理和皮沟处具有独特的皮肤镜图像特征。良性痣的色素沉着通常位于皮沟，而恶性黑色素瘤的色素沉着位于皮嵴。基于传统的垂直病理图像，已经研究了足底色素病变的皮肤镜与病理学之间的对应关系。然而，为了全面了解对应关系，需要观察水平组织学图像，因为表皮构建了独特的水平结构，即深限嵴、中深限嵴和横向嵴。在这项研究中，我们通过水平组织学图像分析了代表性肢端黑素细胞病变（痣、雀斑和恶性黑色素瘤）的基本皮肤镜图像。我们通过对一百张连续垂直图像的数字重建创建了连续的水平病理图像。我们可以表明，平行的皮沟模式是由深限嵴的色素沉着形成的，平行的嵴模式是由深限嵴和中深限嵴的色素沉着形成的，而网格状模式是由横向嵴的色素沉着形成的。我们的结果将有助于直观地了解皮肤镜的组织学。
