College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
Macromol Biosci. 2021 Jul;21(7):e2100109. doi: 10.1002/mabi.202100109. Epub 2021 Apr 28.
Injectable dual crosslinking hydrogels hold great promise to improve therapeutic efficacy in minimally invasive surgery. Compared with prefabricated hydrogels, injectable hydrogels can be implanted more accurately into deeply enclosed sites and repair irregularly shaped lesions, showing great applicable potential. Here, the current fabrication considerations of injectable dual crosslinking hydrogels are reviewed. Besides, the progress of the hydrogels used in corresponding applications and emerging challenges are discussed, with detailed emphasis in the fields of bone and cartilage regeneration, wound dressings, sensors and other less mentioned applications for their more hopeful employments in clinic. It is envisioned that the further development of the injectable dual crosslinking hydrogels will catalyze their innovation and transformation in the biomedical field.
可注射双交联水凝胶在微创外科中提高治疗效果方面具有巨大的应用潜力。与预制水凝胶相比，可注射水凝胶可以更精确地植入到深部封闭部位，并修复形状不规则的病变，具有很大的应用潜力。本文综述了可注射双交联水凝胶的当前制备考虑因素。此外，还讨论了相应应用中使用的水凝胶的进展和新出现的挑战，并详细强调了在骨和软骨再生、伤口敷料、传感器等领域的应用，这些领域在临床上有更广阔的应用前景。可以预见，可注射双交联水凝胶的进一步发展将促进其在生物医学领域的创新和转化。
