State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, China.
Int J Artif Organs. 2021 Dec;44(12):980-989. doi: 10.1177/03913988211013046. Epub 2021 Apr 28.
Blood flow inside the left ventricle (LV) is a concern for blood pump use and contributes to ventricle suction and thromboembolic events. However, few studies have examined blood flow inside the LV after a blood pump was implanted. In this study, in vitro experiments were conducted to emulate the intraventricular blood flow, such as blood flow velocity, the distribution of streamlines, vorticity and the standard deviation of velocity inside the LV during axial blood pump support. A silicone LV reconstructed from computerized tomography (CT) data of a heart failure patient was incorporated into a mock circulatory loop (MCL) to simulate human systemic circulation. Then, the blood flow inside the ventricle was examined by particle image velocimetry (PIV) equipment. The results showed that the operating conditions of the axial blood pump influenced flow patterns within the LV and areas of potential blood stasis, and the intraventricular swirling flow was altered with blood pump support. The presence of vorticity in the LV from the thoracic aorta to the heart apex can provide thorough washing of the LV cavity. The gradually extending stasis region in the central LV with increasing blood pump support is necessary to reduce the thrombosis potential in the LV.
左心室（LV）内的血流是血液泵使用的关注点，会导致心室抽吸和血栓栓塞事件。然而，很少有研究检查血液泵植入后 LV 内的血流。在这项研究中，进行了体外实验以模拟 LV 内的血流，例如血流速度、流线分布、涡度和 LV 内速度的标准偏差，在轴向血液泵支持期间。从心力衰竭患者的计算机断层扫描（CT）数据重建的硅酮 LV 被纳入模拟循环回路（MCL）以模拟人体全身循环。然后，使用粒子图像测速（PIV）设备检查心室内部的血流。结果表明，轴向血液泵的工作条件会影响 LV 内的流动模式和潜在的血液停滞区域，并且随着血液泵的支持，LV 内的回旋流会发生变化。从胸主动脉到心脏顶点的 LV 中的涡度存在可以为 LV 腔提供彻底的冲洗。随着血液泵支持的增加，LV 中央逐渐扩展的停滞区域对于减少 LV 中的血栓形成潜力是必要的。
