基于卟啉体的光动力 O 经济器通过抑制线粒体呼吸治疗缺氧肿瘤。
A porphysome-based photodynamic O economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration.
机构信息
Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P. R. China.
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, P. R. China.
出版信息
Chem Commun (Camb). 2021 Apr 27;57(34):4134-4137. doi: 10.1039/d1cc00544h.
A porphysome-based photodynamic O2 economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy.
一种基于卟啉体的光动力 O2 节约剂 (P-PAT) 被制备用于缺氧肿瘤治疗。P-PAT 的自组装卟啉双层具有高载药量的阿托伐醌 (ATO)（接近 70%），可以抑制线粒体呼吸以缓解缺氧并增强光动力治疗。
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