Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
Biomater Sci. 2021 Jun 4;9(11):4066-4075. doi: 10.1039/d1bm00085c.
Disseminated tumor cells in bleeding and residual tumor cells in the resection tumor site are the primary factors that result in tumor recurrence after surgery. Safe and efficient local implantation of the drug depot system into the resection cavity to inhibit tumor recurrence would be of great benefit to reduce the mortality of postoperative patients. Here, a sandwich-like doxorubicin-triptolide-loaded fiber/(chitosan/gelatin) sponge, DTF/CGS, is fabricated, combining hemostatic, antibacterial, and chemotherapeutic capability. The CGS obtained via freeze-drying can efficiently prevent bleeding; meanwhile, the metastatic residual tumor cells are stuck with the clotted absorbed blood. Subsequently, dual drugs released from the electrospun fiber can further kill the stuck tumor cells in CGS and the disseminated tumor cells to significantly inhibit the tumor recurrence. This antitumor recurrence strategy by immediately implanting a multifunctional hybrid sponge for in situ postoperative management may possess great potential for preventing tumor recurrence.
播散的肿瘤细胞和残留在切除肿瘤部位的肿瘤细胞是导致手术后肿瘤复发的主要因素。将药物储存库系统安全有效地植入切除腔以抑制肿瘤复发，将极大地有助于降低术后患者的死亡率。在这里，构建了一种三明治样的多柔比星-雷公藤内酯醇负载纤维/（壳聚糖/明胶）海绵 DTF/CGS，结合了止血、抗菌和化疗能力。通过冷冻干燥获得的 CGS 可以有效地防止出血；同时，凝结的吸收血液会黏附转移的残留肿瘤细胞。随后，电纺纤维释放的两种药物可以进一步杀死 CGS 中的黏附肿瘤细胞和播散的肿瘤细胞，从而显著抑制肿瘤复发。这种通过立即植入多功能混合海绵进行原位术后管理的抗肿瘤复发策略，可能具有预防肿瘤复发的巨大潜力。
