Tsai C M, Perng R P, Huang W L
Chest Department, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Cancer Detect Prev. 1988;11(3-6):235-8.
Seventy-six patients less than 40 years of age were diagnosed from 1970 to 1983 as having lung cancer. We compared the smoking history, clinical features, cell types, and treatments in this series with those of 804 patients with primary lung cancer aged 40 or more. In the present study the association between smoking and lung cancer in young Chinese was substantially weaker (only 41.1% were smokers). The high incidences of adenocarcinoma (59.2%) and poorly differentiated carcinoma (11.8%) and the small number of epidermoid carcinoma (13.2%) in the young contrasted with those in the older patients. Though the young patients had relatively delayed diagnosis and more advanced disease, they did not have significantly poorer resectability and worse prognosis. But the 19 patients (25%) aged 30 or less ran a more virulent course.
1970年至1983年间,76名年龄小于40岁的患者被诊断患有肺癌。我们将该组患者的吸烟史、临床特征、细胞类型及治疗情况与804名年龄40岁及以上的原发性肺癌患者进行了比较。在本研究中,中国年轻人吸烟与肺癌之间的关联明显较弱(吸烟者仅占41.1%)。年轻人中腺癌的高发病率(59.2%)、低分化癌的高发病率(11.8%)以及表皮样癌数量较少(13.2%),与老年患者形成对比。尽管年轻患者的诊断相对延迟且疾病更晚期,但他们的可切除性和预后并没有明显更差。不过,19名年龄在30岁及以下的患者(25%)病情发展更为凶险。