有机光氧化还原催化的环状亚胺与环状脂肪族伯胺的 C(sp)-N 交叉偶联反应。
An organophotoredox-catalyzed C(sp)-N cross coupling reaction of cyclic aldimines with cyclic aliphatic amines.
机构信息
College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China.
Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, China.
出版信息
Org Biomol Chem. 2021 Apr 28;19(16):3595-3600. doi: 10.1039/d1ob00223f.
An organophotocatalyzed C(sp2)-H/N-H cross-dehydrogenative coupling of cyclic aldimines with aliphatic amines has been developed, which represents the first example of visible-light-induced C-H amination of N-sulfonylated imines. This methodology enables the streamline assembly of amine derivatives via radical mediated C-N bond formation. The current protocol features transition-metal-free, mild conditions, good functional group tolerance and good yields.
发展了一种有机光催化的 C(sp2)-H/N-H 交叉脱氢偶联反应，用于环状亚胺与脂肪族伯胺的反应，这代表了首例可见光诱导的 N-磺酰亚胺 C-H 胺化反应的实例。该方法通过自由基介导的 C-N 键形成，实现了胺衍生物的高效构建。该反应具有无需过渡金属、条件温和、官能团容忍性好、产率高等优点。
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