Hölzel W G
Institute of Pathological and Clinical Biochemistry, Charite Hospital, Humboldt University, Berlin, G.D.R.
Clin Chem. 1988 Jul;34(7):1485-8.
Biological intra-individual CVs for Na+, Cl-, K+, calcium, cholesterol, high-density lipoprotein cholesterol, triglycerides in serum, and hemoglobin in blood were estimated in men with essential hypertension (EH) treated with beta-blockers and diuretics, and compared with those of normotensive men. Although in EH the mean concentrations of Na+, Cl-, K+, hemoglobin, and triglycerides were increased and that of HDL cholesterol was decreased, the average intra-individual CVs did not significantly differ between the two groups. The mean concentration of cholesterol, as well as the average intra-individual CV for it, was significantly higher in EH. There was no correlation between the intra-individual CVs for the analytes and the mean blood pressure of the individuals. Individual values were normally distributed for all analytes. There was no increase of the intra-individual CV with the lapse of time between consecutively measured values. The estimated average biological intra-individual CV was used to derive decision-making criteria for interpretation of test results observed in monitoring EH.
对接受β受体阻滞剂和利尿剂治疗的原发性高血压（EH）男性患者的血清中Na⁺、Cl⁻、K⁺、钙、胆固醇、高密度脂蛋白胆固醇、甘油三酯以及血液中的血红蛋白的生物个体内变异系数（CV）进行了估算，并与血压正常男性的这些指标进行了比较。尽管在EH患者中，Na⁺、Cl⁻、K⁺、血红蛋白和甘油三酯的平均浓度升高，而高密度脂蛋白胆固醇的平均浓度降低，但两组之间的平均个体内CV没有显著差异。EH患者中胆固醇的平均浓度及其平均个体内CV均显著更高。分析物的个体内CV与个体的平均血压之间没有相关性。所有分析物的个体值均呈正态分布。连续测量值之间的时间间隔推移并没有导致个体内CV增加。估算的平均生物个体内CV用于推导在监测EH时观察到的检测结果解释的决策标准。
